ynic-users

ynic-users@ynic.york.ac.uk

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Upgrades and changes
by Antony Morland 24 Sep '18

24 Sep '18

Hello All, We are now open after our summer closure for upgrades and maintenance. As always, please let us know if there is anything that no longer functions as it did and we will try to rectify the situation. Here is a summary of what has been updated/upgraded during the closure: *Software*: FSLeyes upgraded to most recent version (0.26.1) Psychopy upgraded to 1.90.3 including changes to video handling (addition of moviepy and sounddevice) Matlab 9.4 added; no Matlab versions removed; 9.0 will be removed in January. Libreoffice upgraded to 6.1 Crossover Office upgraded to 17.5 Mendeley upgraded to latest release SPM 12 upgraded to latest patch (r7219) Windows is no longer supported on the Stimulus PCs *Hardware changes:*New cabling of offices Networking improvements Telephony updated New chiller installed for GE system - this should be completed by tomorrow *Estate:* The Chemistry areas have been reconfigured and rationalized Best wishes Tony -- Antony Morland, PhD. Director, York Neuroimaging Centre Department of Psychology, University of York, York YO10 5DD, UK.

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Email addresses
by Antony Morland 24 Sep '18

24 Sep '18

Hello All, We have received (indirectly) some emails asking for help. They were posted to rec-submission(a)ynic.york.ac This is the address to send ethics applications, not a email queue that we monitor for general issues. To avoid undue delays please send requests for help etc to support(a)ynic.york.ac.uk Many thanks Tony -- Antony Morland, PhD. Director, York Neuroimaging Centre Department of Psychology, University of York, York YO10 5DD, UK.

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Fwd: REMINDER - SEMINAR INFO: JEOL Postdoc Competition Winners' Seminar & refreshments, TOMORROW, 13:00, C/A/101
by Antony Morland 20 Sep '18

20 Sep '18

The second talk described below may be of interest *JEOL Postdoc Competition Winners’ Seminar * *Thursday 20th September * *13.00-15.00* *C/A101* *13.00 Dr. Aggie Lawer* *"Synthesis of functionalised peptides/macrocycles and medium-size **rings via stereoselective fluorination and SuRE/NICE chemistry"* Insertion of fluorine into organic molecules is well-known to affect the molecules’ electronic distribution and conformation in ways that can be beneficial in drug development. However, the effects of fluorination have not been widely investigated in the context of peptides, which limits the development of peptide-based drugs. In the first part of the talk, I will discuss how stereoselective fluorination was used to control the conformations of peptides and enhance the potency of a peptide-based enzyme inhibitor. While peptides/macrocycles and medium-size rings have recently gained noteworthy interest in the area of medicinal chemistry, their synthesis is mostly limited to the traditional end-to-end macrocyclisations which suffer from unfavourable thermodynamic factors, and oftentimes require the use of high dilution conditions. In the second part of my talk, I’ll describe how Successive Ring Expansion (SuRE) and N-acyl Iminium ion mediated Cyclisation/Expansion (NICE) reactions developed in Unsworth group could be employed to overcome these limitations, providing an efficient, scalable and practical route to make diverse macrocycles and medium-size rings. *13.45 Dr. Peter Rayner * *"Tunable Hyperpolarisation by Synthetic Design"* NMR and MRI are two of the most popular techniques to study molecules and materials. However, both of these approaches are insensitive and hyperpolarization methods to increase signal size are needed in order to access new applications. This talk will describe how rational synthetic design of both the contrast agents and N-heterocyclic carbene catalysts utilized in the Signal Amplification by Reversible Exchange process, have led to signals that are up to 120,000 times larger than those achieved on a typical hospital scanner and can be observed many minutes after their creation. These improvements have allowed the observation of hyperpolarized molecules by in vivo MRI techniques. *The seminar will be followed at 14.30 by refreshments* -- Antony Morland, PhD. Director, York Neuroimaging Centre Department of Psychology, University of York, York YO10 5DD, UK.

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Remote desktop
by Antony Morland 17 Sep '18

17 Sep '18

Hello All, The Remote Desktop is now up and running. We are still closed for maintenance and upgrades so while we hope the service will run uninterrupted, there may be unplanned outages. Best wishes Tony -- Antony Morland, PhD. Director, York Neuroimaging Centre Department of Psychology, University of York, York YO10 5DD, UK.

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GE update
by Antony Morland 28 Aug '18

28 Aug '18

Apologies, All, the GE scanner is down until further notice. The water chiller that we have been having difficulties with has finally given up the ghost. Plans for replacement are underway. Best wishes Tony -- Antony Morland, PhD. Director, York Neuroimaging Centre Department of Psychology, University of York, York YO10 5DD, UK.

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Some updates
by Antony Morland 21 Aug '18

21 Aug '18

Hello All, 1. A day for your diaries: 14th September 'YNiC Science Day' will be held in B020. More details to follow from Jonny nearer the time. 2. YNiC will be close 11th September to reopen 24th September. This will allow for our annual maintenance and upgrades to the centre. 3. As many of you may know, we had a significant period of unscheduled down time on the GE scanner. The problem has now been fixed. Best wishes Tony -- Antony Morland, PhD. Director, York Neuroimaging Centre Department of Psychology, University of York, York YO10 5DD, UK.

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YNiC Science Day_September 14th_Call for existing conference posters
by Magdalena Sliwinska 20 Aug '18

20 Aug '18

Dear All, *The Science Day 2018*, held in our department, is slowly approaching us. During that day, Jonny and I would like to display posters that YNiC users, especially ECRs, have presented at conferences over the last year. If any of you have posters buried in dust in the dark corners of your offices and would like them to see a daylight again, please let us know. NOTE: It is not required to stand next to the poster, so even if you are away on that day, we can still present your awesome work to the department. I will arrange collection of your posters from you, so to make it happen just drop me an email. Many thanks, Magda -- *Magdalena W. Sliwinska, PhD* Research Associate Department of Psychology University of York Heslington, York, YO10 5DD, UK tel: 01904323177

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GE Scanner - repairs underway
by Andre Gouws 30 Jul '18

30 Jul '18

Hi all, I am afraid that the GE scanner is in need of repair that means it may be out of service for at least a week. In light of the recent UK weather patterns, you will probably not be surprised to hear that this is due to the failure of one of the water chillers. We will keep you updated with the status of the scanner. Best wishes, -- André ************************************************************************ André Gouws PhD Manager of Imaging Services York Neuroimaging Centre University of York The Biocentre York Science Park Heslington YO10 5NY Tel: +44 (0) 1904 435327 Fax: +44 (0) 1904 435356

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Seminar 26th June
by Antony Morland 23 Jul '18

23 Jul '18

Hi All, Our talk on Thursday at 4pm will be.... *Andrew Logan, Bradford University* *Title:* Quantifying impairments of face perception in age-related macular degeneration *This project aimed to develop a new method of testing face perception ability which is suitable for use in a clinical environment. Our data quantify the impact of age-related macular degeneration- the leading cause of irreversible visual impairment in the UK- on face perception; an everyday visual function with links to quality of life.* Refreshments available afterwards Best wishes -- Antony Morland, PhD. Director, York Neuroimaging Centre Department of Psychology, University of York, York YO10 5DD, UK.

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Project presentation: Thursday 19th
by andre＠ynic.york.ac.uk 18 Jul '18

18 Jul '18

Hi all, We will be hosting a project presentation by Sara Stampacchia at YNiC tomorrow (Thurs 19th) at 4pm: “Exploring the neural substrate of control over memory representations”. Please join us for the presentation and discussion to be followed by light refreshments. Best wishes, André ************************************************************************ André Gouws PhD Manager of Imaging Services York Neuroimaging Centre University of York The Biocentre York Science Park Heslington YO10 5NY Tel: +44 (0) 1904 435327 Fax: +44 (0) 1904 435356

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