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10 Nov '10

Dear Users Today from 4-5 pm in YNiC open plan, Susanne Weis and Markus Hausmann will be giving YNiC project proposal presentations. i) Susanne Weis: "Object location memory: Differences between verbal and non-verbal strategies during memory encoding and retrieval" It has repeatedly been shown that the medial temporal lobe (MTL), and especially the hippocampus, play an important role during memory encoding and retrieval. Specifically,activation of the hippocampus has been related to associative and contextual memory and binding of an item with its context. It is therefore assumed, that the hippocampus interacts with cortical regions during object location memory (OLM) tasks, where an object has to be bound to its spatial location. A variety of studies have shown that men on average perform better than women in specific aspects of spatial cognition. On the other hand, women have been shown to be superior in OLM tasks. One explanation which has been proposed for this findings suggests that women use verbal strategies during OLM encoding and retrieval, while man rely more on spatial strategies. It can be assumed that different strategies during OLM task are linked to different patterns of brain activation. It is the aim of our study to examine functional connectivity between the hippocampus and cortical areas during encoding and retrieval of an OLM task. Further, we intend to find out if inter-individual differences in strategies result in changes of patterns of brain activation and the functional connectivity within these networks. ii) Markus Hausmann: "Sex hormonal effects on the functional connectivity within and across hemispheres in postmenopausal women" Previous research in postmenopausal women has shown that hormone therapy (HT), and estrogen therapy (ET) in particular, affects the functional brain organization such as interhemispheric integration and functional cerebral asymmetries (FCAs) (Bayer & Erdmann, 2008; Bayer & Hausmann, 2009a,b; Bayer & Hausmann, 2010). The results suggest that these effects are mediated by the neuromodulatory properties of estradiol on intrahemispheric functional networks. Specifically, it seems that estradiol enhances verbal processing at the expense of visuo-spatial processing within the right hemisphere. This idea might explain why several studies found divergent effects of HT on verbal and visuo-spatial cognition (including verbal and non-verbal memory). Moreover, estradiol-related effects on FCAs have also been demonstrated in normally cycling women during hormonal distinct cycle-phases (Weis et al., 2008). Specifically, this fMRI study found estradiol-related changes in the interhemispheric inhibition between homotopic areas in the inferior frontal gyrus of the left and right hemispheres. The present study is set out to elucidate whether HT-related changes in FCAs as measured by a verbal and visuo-spatial visual half-field tasks in postmenopausal women might be subserved by changes in the functional connectivity between cortical networks within and across hemispheres. Everyone is welcome to attend. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminars this week
by rem 08 Nov '10

08 Nov '10

Dear Users Please note that there will be two YNiC seminars this week; one at the usual time on Thursday and an additional seminar on Wednesday afternoon. On Wednesday Dr. Susanne Weis and Dr. Markus Hausmann, from the University of Durham, will give project proposal presentations from 4-5 pm: Dr. Susanne Weis: "Object location memory: Differences between verbal and non-verbal strategies during memory encoding and retrieval" Dr. Markus Hausmann: ""Sex hormonal effects on the functional connectivity within and across hemispheres in postmenopausal women" On Thursday there will be 3 project proposal presentations by Prof. David Lurie, Prof. Thomas Redpath and Dr. Hugh Seton from the University of Aberdeen: Prof. David Lurie: ""Field-Cycling Magnetic Resonance Imaging" Prof. Thomas Redpath: "Dynamic contrast-enhanced MRI in breast cancer" Dr. Hugh Seton: "Ultra-low field MRI with cooled receiver coils and SQUID preamplifiers" Please see below for further information about each talk. Everyone is welcome to attend and refreshments will be available afterwards. Best wishes Rebecca *1) Wednesday 10th November * i) Susanne Weis "Object location memory: Differences between verbal and non-verbal strategies during memory encoding and retrieval" It has repeatedly been shown that the medial temporal lobe (MTL), and especially the hippocampus, play an important role during memory encoding and retrieval. Specifically,activation of the hippocampus has been related to associative and contextual memory and binding of an item with its context. It is therefore assumed, that the hippocampus interacts with cortical regions during object location memory (OLM) tasks, where an object has to be bound to its spatial location. A variety of studies have shown that men on average perform better than women in specific aspects of spatial cognition. On the other hand, women have been shown to be superior in OLM tasks. One explanation which has been proposed for this findings suggests that women use verbal strategies during OLM encoding and retrieval, while man rely more on spatial strategies. It can be assumed that different strategies during OLM task are linked to different patterns of brain activation. It is the aim of our study to examine functional connectivity between the hippocampus and cortical areas during encoding and retrieval of an OLM task. Further, we intend to find out if inter-individual differences in strategies result in changes of patterns of brain activation and the functional connectivity within these networks. ii) Markus Hausmann "Sex hormonal effects on the functional connectivity within and across hemispheres in postmenopausal women" Previous research in postmenopausal women has shown that hormone therapy (HT), and estrogen therapy (ET) in particular, affects the functional brain organization such as interhemispheric integration and functional cerebral asymmetries (FCAs) (Bayer & Erdmann, 2008; Bayer & Hausmann, 2009a,b; Bayer & Hausmann, 2010). The results suggest that these effects are mediated by the neuromodulatory properties of estradiol on intrahemispheric functional networks. Specifically, it seems that estradiol enhances verbal processing at the expense of visuo-spatial processing within the right hemisphere. This idea might explain why several studies found divergent effects of HT on verbal and visuo-spatial cognition (including verbal and non-verbal memory). Moreover, estradiol-related effects on FCAs have also been demonstrated in normally cycling women during hormonal distinct cycle-phases (Weis et al., 2008). Specifically, this fMRI study found estradiol-related changes in the interhemispheric inhibition between homotopic areas in the inferior frontal gyrus of the left and right hemispheres. The present study is set out to elucidate whether HT-related changes in FCAs as measured by a verbal and visuo-spatial visual half-field tasks in postmenopausal women might be subserved by changes in the functional connectivity between cortical networks within and across hemispheres. *2) Thursday 11th November * i) Prof. David Lurie "Field-Cycling Magnetic Resonance Imaging" Contrast between normal and diseased tissue in MRI arises mainly from differences in relaxation times. It is also well known from in vitro studies that the variation of T1 with field strength (T1 dispersion) changes from tissue to tissue, and may also be altered in disease. Thus, it is potentially useful to be able to measure T1 dispersion in vivo; however, this information cannot be obtained by conventional MRI scanners, which operate at fixed magnetic field. We are developing field-cycling MRI systems, in which the magnetic field is switched rapidly between levels during the pulse sequence, always returning to the same field for signal measurement. FC-MRI offers the possibility of new image contrast mechanisms based on T1 dispersion. In particular, immobilised proteins give rise to "quadrupole dips" in the dispersion curve, and this mechanism may give insight into the behaviour (and misbehaviour) of proteins in disease. This talk will discuss the methodology, technology and applications of FC-MRI. ii) Prof. Thomas Redpath "Dynamic contrast-enhanced MRI in breast cancer". My talk will cover the basic physiology underlying dynamic contrast-enhanced MRI, the scanning methods used, and will describe the pharmaco-kinetic models used in analysing the signal versus time curves which are seen in breast cancers. The need for arterial input functions in the newer models will be discussed and a novel approach which we have proposed will be outlined. The particular problem of scanning at 3 tesla, namely RF pulse angle variation across the body, and methods of overcoming it will also be covered. iii) Dr. Hugh Seton "Ultra-low field MRI with cooled receiver coils and SQUID preamplifiers" "The presentation will describe MRI developments at 10-20mT. Imaging at such low fields has the potential to deliver improved contrast compared to high field, partly because T1 differences between tissues can increase at low field but also because there is greater flexibility to employ contrast-enhancing pulse sequences which would exceed RF power deposition limits at high field. Normally the SNR is poor at low field, but we have developed cooled receiver coils and ultra-low noise SQUID preamplifiers that yield 3-6 fold SNR gains compared to conventional room temperature coils." -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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Neuroscience Job in Italy
by Silke Goebel 05 Nov '10

05 Nov '10

*Assistant or Associate Research Professors, Center for Mind/Brain Sciences, Trento * The Center for Mind/Brain Sciences (CIMeC) at the University of Trento is seeking to fill a number of research positions in cognitive neuroscience at the Assistant or Associate Research Professor level. The Center offers an international and vibrant research setting in which to investigate the functioning of the brain through the analysis of its functional, structural and physiological characteristics, in both normal and pathological states. Researchers at the Center make use of state-of-the-art neuroimaging methodologies, including a research-only MRI scanner, MEG, EEG and TMS, as well as behavioral, eye tracking and motion tracking laboratories. The Center also includes a neuropsychology and neuro-rehabilitation clinic (CERiN). The Center strongly encourages collaborative and innovative research, and provides the opportunity for all researchers to access laboratory resources and to be part of the Doctoral School in Cognitive and Brain Sciences. CIMeC also has close collaborations with local research centers, including FBK (Fondazione Bruno Kessler) and IIT (Italian Institute of Technology), through joint projects and through the doctoral school. Further information about the Center can be found at: http://www.cimec.unitn.it <http://www.cimec.unitn.it/>. The ideal researchers (from all areas of cognitive neuroscience, including computational neuroscience and neuroimaging methods) must hold the Ph.D. or M.D. degree, and should have a record documenting research creativity, independence, and productivity. We are looking for researchers able to build and maintain a high quality research program and to contribute to the maintenance of a collegial and collaborative academic environment. For more information see attachment. -- Dr Silke Goebel Department of Psychology University of York Heslington York YO10 5DD UK Tel: +44 (0) 1904 32 2872 Email: s.goebel(a)psych.york.ac.uk Web: http://www.york.ac.uk/res/crl/sgoebel.html TMS Lab: http://www.york.ac.uk/res/tms EMAIL DISCLAIMER http://www.york.ac.uk/docs/disclaimer/email.htm

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Open Plan busyness
by Sam Johnson 04 Nov '10

04 Nov '10

Hello all, Just to let people know that between 1:15 and 3:15 this afternoon, YNiC's open plan will be very busy with the MSc course practical. This year we're pretty much at capacity so there won't be any spare machines. Those of you who are coming up for the seminar and thought about coming early to get a bit of quiet work done, I'm not sure that'll be possible I'm afraid. Apologies to those who were unable to work last week, for future reference Thursday afternoons for the next 6 weeks will be equally busy, though I'll send reminders. Thanks, Sam -- Sam Johnson Science Manager, York NeuroImaging Centre University of York http://www.ynic.york.ac.uk

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YNiC seminar today
by rem 04 Nov '10

04 Nov '10

Dear Users Mark Hymers will be giving a presentation from 4-5 pm in YNiC open plan today. The title of Mark's talk is "YNiC MEG Analysis Software Update". Everyone is welcome to attend and refreshments will be available afterwards. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminar 4th November
by rem 01 Nov '10

01 Nov '10

Dear Users This week Mark Hymers will be giving a presentation on Thursday afternoon (4-5 pm) in YNiC open plan. The title of Mark's talk is "YNiC MEG Analysis Software Update". Everyone is welcome to attend and refreshments will be available afterwards. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminar today
by rem 28 Oct '10

28 Oct '10

Dear Users This afternoon (4-5 pm) there will be two presentations in YNiC open plan: 1) A project proposal presentation on "Neural correlates of semantic richness for familiar and newly-learned words" by Roberto Ferreira, Department of Psychology. 2) A talk on MEG methods by Sam Johnson, YNiC, titled "Lagrangians, orientations and spatial filters". Everyone is welcome to attend and refreshments will be available afterwards. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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[Fwd: Re: MEGUK10]
by Gary Green 27 Oct '10

27 Oct '10

Dear Colleagues Below is an invitation to attend the next MEGUK meeting. It will be held in Glasgow in January. As you can read, there will be slots for each MEG site to present their work and there will also be opportunities for poster presentations. They are keen that each site co-ordinates their own contributions. Although it says that I am the contact point, Michael Simpson michael.simpson(a)ynic.york.ac.uk is actually going to do the co-ordination. Thanks Michael. If you are going to attend, please can you contact Michael, as well as register as indicated below Gary ---------------------------- Dear all, the next MEG users UK meeting will be in Glasgow on the 29th (Saturday) and 30th (Sunday) of January 2011. We will have 1 hour oral presentations per MEG site (it is up to each site how many presentations they wish to fit into their 60 min) and to have an extensive poster session on Saturday evening (we can accommodate around 100 posters). Registration is now open (no fee, no costs). Simply click on the link below that will take you to a website where you please enter your name, your email address, and your affiliation. Your email will be automatically added to an alias (meguk2011(a)psy.gla.ac.uk <mailto:meguk2011@psy.gla.ac.uk>) which, eventually, will be used as the only means for disseminating information about the meeting, so please make sure that your email address is correct. link to registration: http://marc-web.psy.gla.ac.uk/MEGUK2011/ Please forward this email to everyone I have left out including my apologies. Also apologies in case you have received this email by mistake - once we switch to the alias you will be safe. Most contributions will be posters this time. We will have a long poster session on Saturday night with a buffet, which will give us plenty of time to socialise in front of the posters. If you wish to give an oral presentation please get in touch with your local contact, but please note that all talks from a single site have to be fitted within the allocated 1 hour slot. List of contacts: Cardiff (Krish Singh) Cambridge (Rick Henson) York (Gary Green) Oxford (Sven Braeutigam) London (Gareth Barnes) Nottingham (Matt Brookes) Aston (Paul Furlong) Glasgow (Klaus Kessler) Best wishes Klaus, on behalf of the organizing committee Committee: Joachim Gross Klaus Kessler (Chair) Sebastien Miellet Nicola Van Rijsbergen Heng-Ru May Tan -- Gary Green York Neuroimaging Centre The Biocentre York Science Park Innovation Way Heslington York YO10 5DG http://www.ynic.york.ac.uk https://www.ynic.york.ac.uk/about-us/people/ggrg tel. +44 (0) 1904 435349 PA (Claire Fox) +44 (0) 1904 435329 fax +44 (0) 1904 435356 mobile +44 (0) 788 191 3004

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YNiC seminar 28th Oct
by rem 25 Oct '10

25 Oct '10

Dear Users This week there will be two presentations on Thursday afternoon (4-5 pm) in YNiC open plan: 1) A project proposal presentation on "Neural correlates of semantic richness for familiar and newly-learned words" by Roberto Ferreira, Department of Psychology. 2) A talk on MEG methods by Sam Johnson, YNiC, titled "Lagrangians,* *orientations and spatial filters". Everyone is welcome to attend and refreshments will be available afterwards. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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[Fwd: two positions available at CHB/HMS]
by Gary Green 19 Oct '10

19 Oct '10

FYI ---------------------- To members of the MEG community, Children's Hospital Boston (CHB), Harvard Medical School, is in the process of starting an MEG research program as part of the hospital-wide effort to develop a multimodal neuroimaging center for studying human brain development ranging from the fetus in utero, to prematurely born babies and up to preschool children in hospital setting. We now have the two following positions we hope to fill immediately. (1) MEG Systems Technician - management of the hardware and software of the babySQUID prototype initially and eventually a whole-head babySQUID II, assistance in data acquisition and analysis. Minimum requirement: MS or its equivalent in engineering (biomedical, electrical or computer engineer), excellent command of English (speech and writing). (2) Research Technician - assistance in day-to-day operation of the MEG facility, assistance in data acquisition and analysis. Minimum requirement: BS/BA or its equivalent in engineering, excellent command of English (speech and writing) with good people skill If you are interested in one of these positions, please send me an email. I will forward your email to the CHB's Human Resources which will provide you with the job description and other details of the position. You will be joining a rapidly growing team of researchers that includes experts in mathematical modeling of the CNS, signal analysis, multimodal integration, experimentation, EEG, MRI including tractography, NIRS, basic and clinical research in neuroscience and perinatology and clinical medicine. Our group will be studying both inpatients and outpatients as well as healthy controls. Yoshio Okada MEG Director Neuroimaging and Brain Development Science Center (Director: Ellen Grant) CHB/HMS

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