FYI *Postdoctoral Fellowship in MRI Research* *University of California at Los Angeles, Los Angeles* This NIH-funded postdoctoral research position is supported with the aim to determine whether the white matter injury in obstructive sleep apnea (OSA), a common and progressive syndrome accompanied by severe cardiovascular, metabolic, memory, emotional, and cognitive deficits, presumably stemming from compromised neural processes induced by intermittent hypoxia and perfusion changes accompanying the condition, results from myelin or axonal damage, and whether those changes are in acute or chronic stages in the condition. The pathological stage of white matter injury will be examined by diffusion tensor imaging (DTI) and diffusional kurtosis imaging (DKI)-based mean diffusivity and mean kurtosis indices. Myelin vs axonal changes will be assessed by DTI and DKI-based axial diffusivity and axial kurtosis, and radial diffusivity and radial kurtosis measures, which show axonal and myelin changes, respectively. We will use both DTI and DKI techniques, since each procedure offers unique advantages. More detailed myelin evaluation will also be performed by magnetization transfer imaging procedures. Finally the number of fibers, mean length, and other fiber characteristics will be evaluated by DTI-based fiber tractography procedures. Our lab is part of neuroscience community at UCLA, the largest neuroscience community in the nation, host a large number of neuroscientists (>500), who provide a resource for neuroanatomic, neuropathologic, neurophysiologic, neuropsychologic, and analytic support. The laboratory is immediately adjacent to the Ahmanson-Lovelace Brain Mapping Center, which provides a significant resource in neuroimaging faculty (>28 faculty, both basic and clinical), software, and analytic support, and there are ample of opportunities to interact those scientists. Our lab uses a 3.0 Tesla (Siemens, Tim-Trio) MRI scanner, located in the proximal Department of Radiology Research laboratory, a unit devoted to research studies with on-site Ph.D.-level Siemens engineers. A PhD in radiology, mathematics, biology, biomedical engineering, neuroscience or related field with strong background and research experience in MRI-related research in humans, reflected as data based publications, is required. Experience in MRI data acquisition, data processing, and MATLAB-based programming is also desirable. * * Salary is commensurate with research experience. UCLA is an equal opportunity and affirmative action employer (http://www.mednet.ucla.edu/), and all qualified individuals are encouraged to apply. Applications will be accepted until position is filled. To be considered for this position, please send your CV and a cover letter to: Rajesh Kumar, PhD Ronald M. Harper, PhD Department of Neurobiology or Department of Neurobiology University of California at Los Angeles, University of California at Los Angeles, Los Angeles, CA 90095 Los Angeles, CA 90095 Email: rkumar(a)mednet.ucla.edu Email: rharper(a)ucla.edu <mailto:rharper@ucla.edu> -- Rajesh Kumar, PhD Assistant Researcher Department of Neurobiology David Geffen School of Medicine at UCLA University of California at Los Angeles Los Angeles, CA 90095 Tel: 310-206-1679 Email:rkumar@mednet.ucla.edu ------------------------------------------------------------------------ IMPORTANT WARNING: This email (and any attachments) is only intended for the use of the person or entity to which it is addressed, and may contain information that is privileged and confidential. You, the recipient, are obligated to maintain it in a safe, secure and confidential manner. Unauthorized redisclosure or failure to maintain confidentiality may subject you to federal and state penalties. If you are not the intended recipient, please immediately notify us by return email, and delete this message from your computer.