We are looking to recruit a couple of post-docs to CUBRIC in functional neurovascular imaging. One would be to work with me developing quantitative FMRI methods (3 year post) and the other is to work with Dr Kevin Murphy (Wellcome Fellow) on neurovascular coupling (2 year post). Pasted below is an advert for each one.

Best wishes to all.

Richard Wise FMRI Director CUBRIC School of Psychology University of Cardiff Park Place Cardiff CF10 3AT

Tel: +44 (0)29 2087 0358 (direct) 0365 (reception) Fax: +44 (0)29 2087 0339 http://psych.cf.ac.uk/cubric/ http://www.cf.ac.uk/research/neuroscience/

---- *JOB 1* ----

*Post-doctoral research associate in quantitative FMRI*

*Job reference number: **860BR***

*Salary: *£30,424 - £36,298 per annum (Grade 6)**

*Period of appointment: *The role is full-time and fixed termfor a duration of 36 months subject to a probationary period**

We are seeking a post-doctoral research associate with a strong interest in the development of neuroimaging methodology. The post-holder would work on a human neuroimaging project, funded by the UK EPSRC, which aims to develop MRI methods for measuring human brain oxygen consumption as a marker of brain function in health and disease. The position will involve developing MRI data acquisition and analysis strategies based around BOLD FMRI and ASL measurement of cerebral blood flow (CBF). The post-holder will be expected to test these new methods in volunteers and in specific groups of neurological patients in collaboration with clinical colleagues. There will also be the opportunity to conduct PET measurements as part of the project.

Applicants should have a first degree in the physical or biological sciences and a relevant PhD. The ability to communicate well with scientific colleagues and participants in our experiments is essential. Candidates should have a good understanding of the biophysics underlying FMRI methods as well as an understanding of relevant cerebral physiology. Research experience in FMRI methods development including quantitative assessment of cerebrovascular physiology would be a distinct advantage, as would experience of image data analysis in a UNIX environment using software such as Matlab.

Potential applicants are encouraged to contact Prof. Richard G Wise (tel: +44 (0)2920870358 oremail: wiserg@cardiff.ac.uk mailto:wiserg@cardiff.ac.uk) to find out more about the role, before submitting a formal application. A job description and further particulars, including details of how to apply, are available at http://www.cardiff.ac.uk/jobs/. The closing date for applications is 10 May 2013.

---- *JOB 2* ----

*Post-doctoral research associate in neurovascular coupling*

*Period of appointment:*24 months subject to a probationary period

*Salary:*£30,424 – £36,298 per annum (Grade 6)

We are seeking a post-doctoral research associate to work closely with Dr. Kevin Murphy in CUBRIC, School of Psychology, Cardiff University on a 5 year research programme funded by the Wellcome Trust. The post-holder will be involved in neuroimaging studies of neurovascular coupling, investigating age-related alterations in the relationship between neural activity and regional blood supply. They will be expected to acquire and analyse MRI/MEG data in both young and elderly volunteers.

The motivation for this research programme stems from the fact that the fMRI BOLD signal is not a direct measure of neuronal activity. When comparing groups using this technique, the implicit assumption that neurovascular coupling properties are equivalent is made. Any alterations in cerebrovascular dynamics lead to BOLD differences that are unrelated to neuronal activity. Using an elderly group as a model for altered coupling, this project will investigate such BOLD differences, not only developing suitable correction strategies to uncover BOLD signal purely related to neural activity but also to use the vascular component as a measure of cerebrovascular health. The post-holder will assist with final objective of research program which is to translate cerebrovascular models that have been developed into young/elderly group comparisons by testing their ability to characterise group differences that are present in MEG-derived neuronal activity measures.

Applicants should be experienced in the analysis of neuroimaging or neurophysiological data and should have / or be due to submit a PhD relevant to this or related fields. The ability to communicate well with scientific colleagues and participants in our experiments is essential. Candidates should have a good understanding of the biophysics underlying FMRI and/or MEG signals and their relationship to neurovascular coupling. Practical experience in the acquisition of neuroimaging data is required.

For informal enquiries please contact Dr. Kevin Murphy (murphyk2@cardiff.ac.uk mailto:murphyk2@cardiff.ac.uk). A job description and further particulars, including details of how to apply, will be available on the Cardiff University jobs website http://www.cf.ac.uk/jobs/ from the 15^th April 2013. The closing date for applications is 10 May 2013.

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