An exciting opportunity has arisen for an ambitious postdoctoral position to lead in the development of The Oxford Study for Biomarkers in Motor Neuron Disease (MND, also known as Amyotrophic Lateral Sclerosis, ALS). The project involves applying state-of-the-art multimodal MRI analysis based in Oxford University’s Centre for Functional Magnetic Resonance of the Brain (FMRIB), including the new 7T scanner. The postholder will be a major part of Oxford’s increasing strength in neurodegenerative disorders, and have the opportunity to develop in new areas of advanced MRI analysis, including its integration with MEG. This post will be fixed-term for 2 years in the first instance (funding secured for further 3 years).

Responsibilities/duties:

*Core* 1. Longitudinal analysis of existing T1-weighted, diffusion-weighted and resting-state fMRI BioMOx datasets 2. Exploration of cross-site standardization and harmonization of imaging datasets, with focus on resting-state fMRI 3. Prospective 3T and 7T T1-weighted, diffusion-weighted and resting-state fMRI analysis in BioMOx Phase 2, and MEG integration

*Additional* 1. Assistance with prospective BioMOx MRI data acquisition 2. Close interaction with FMRIB’s analysis group via Dr Gwenaelle Douaud (resting-state fMRI: Prof. Steve Smith; diffusion imaging: Dr Tim Behrens) and with the neurodegeneration group led by Dr Martin Turner and Prof. Kevin Talbot 3. Participation in local journal clubs 4. Oral presentation and written publication of data 5. Potential supervision of students (medical/MSc/DPhil)

Selection criteria:

*Essential* 1. Significant post-doctoral expertise in structural, diffusion and functional MRI analysis (FSL or SPM) 2. Confidence with statistical and mathematical concepts related to advanced MRI 3. Ability to work independently but interact with others across disciplines

*Desirable* 1. Previous experience in neurodegenerative disease research 2. Confident with oral and written presentation of MRI data 3. Comfortable reviewing MRI publications for journals 4. Interest in helping to develop integration of novel techniques, including spinal cord diffusion imaging, GABA MRS, MEG

For informal enquiries please contact Dr Martin Turner (martin.turner@ndcn.ox.ac.uk) or Dr Gwenaelle Douaud (douaud@fmrib.ox.ac.uk).

Further details available at: https://www.recruit.ox.ac.uk/pls/hrislivedoc/docs/0001099095.pdf If interested, an application should be submitted at: https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.displ...

before 31st May 2013.

Recruitment will continue until a suitable candidate has been found. ------------------------------------------------------------------------------------ Gwenaëlle Douaud, PhD MRC Career Development Fellow

FMRIB Centre, University of Oxford John Radcliffe Hospital, Headington OX3 9DU Oxford UK Tel: +44 (0) 1865 222 523 Fax: +44 (0) 1865 222 717

www.ndcn.ox.ac.uk/team/researchers/gwenaelle-douaud -----------------------------------------------------------------------------------