There is an additional seminar today

At 2pm There will be a talk entitled "NMR and MRI sensitivity enhancement by Parahydrogen Induced Polarization"

by

Kerstin Münnemann Max Planck Institute for Polymer Research, Mainz, Germany

Despite its wide applicability in chemistry, biology and medicine, Nuclear Magnetic Resonance (NMR) spectroscopy still suffers from its inherently low sensitivity. Exploiting the large signal enhancements associated with hyperpolarization techniques, such as Parahydrogen Induced Polarization (PHIP), however, NMR or MRI qualify for monitoring dynamic processes in real time. In this lecture, the synthesis and hyperpolarization of several biocompatible molecules like barbiturates, Vinylpyrrolinidon (blood plasma expander) or Dimethylcarboxylat (precursor to fumarate) will be presented. Polarization transfer to 13C in these molecules by using adequate pulse sequences is demonstrated. Moreover, constant NMR signal enhancement of 1H and 13C is shown using a continuous delivery of parahydrogen by hollow fiber membranes. This allows the acquisition of two-dimensional NMR experiments requiring multiple excitations with constant initial polarization. The membrane technique can be easily extended to produce a continuous flow of a hyperpolarized liquid as will be shown for MRI applications.

All welcome