Dear All
NOTES ON THE YNIC ANALYSIS SUPPORT COLLOQUIUM ON VIRTUAL ELECTRODE
ANALYSES IN MEG, WEDNESDAY 13 FEBRUARY 2008.
The current YNiC MEG tools allow us to create beautiful and
defensible images showing how the brain's responses to stimuli evolve
over time. But beamforming requires the comparison of active windows
with passive windows, and the use of active windows less that 200 ms
long is not recommended. So while moving windows convey a good
initial impression of the progression of neural events, they do not
take full advantage of MEG's potential for looking at the detailed
timing of those events.
There is another issue with beamformed brain maps, which is that it
is not easy to compare results across conditions. You can point out
that there is a significant response in a particular brain region in
one condition of an experiment but not in another, but it could be
that the response just makes it over the threshold in one condition
and just falls below threshold in the other. The absolute difference
in the magnitude of the two responses (or, to be accurate, the
magnitude of the difference between the two active and passive
conditions) may be small.
Virtual electrodes offer the potential for asking intelligent
questions about the strength and time course of events at specific
points in the brain, allowing direct comparisons between conditions
and making better use of the temporal resolution of MEG. Piers
Cornelissen presented the results of some virtual electrode analyses
he and his colleagues have done, comparing responses to different
types of stimuli at different regions of interest in the brain.
Piers showed results in the form of time-frequency histograms
('Stockwell plots'), separating out evoked and induced components of
the total response; also event-related frequency (ERF) plots showing
changes in the amplitude of evoked responses over time. He also
discussed techniques that he and his colleagues have used for making
statistical comparisons across conditions in both types of analysis.
A lengthy and gripping discussion ranged over:
1. The best method to identify regions of interest,
2. How best, having identified a point of interest in a standardised
brain, to identify the corresponding points in individual participant
brains, and
3. What issues are involved in doing individual and group level
analyses, and what would be the best analyses to adopt within YNiC,
at least as interim solutions that will allow research groups to make
progress with these techniques.
Doing virtual electrode analyses at a group level is a complex
business but has strong appeal to a number of researchers. Piers has
a working solution which he and Uzma will document and make
available. In complement to this documentation, YNiC will document
the assumptions and issues associated with Virtual Electrode Analysis
at the group level.
It was also clear in the discussion that connectivity measures
applied to Virtual Electrode analysis are going to be important to
understanding more about the signals recorded in MEG, and more about
how functional interactions involving different regions in the brain
evolve over time. Deep thought will be given to this topic within
YNiC.
Ideas for future fora are welcomed.
Andy Ellis and Michael Simpson
--
Professor Andy Ellis
Department of Psychology
University of York
York YO10 5DD
England
Tel. +44 (0)1904 433140
http://www.york.ac.uk/depts/psych/www/people/biogs/awe1.html
Dear all,
just to say thanks to Andy and Piers for chairing last nights YNiC ASC
session; a digest of which will be forwarded to the User list in due course.
Given that we gave everyone the option to leave at 5pm, but everyone
stayed until 5.30, I'll interpret it to have been and success! It was
good that it generated so much discussion. On which note, would anyone
like to volunteer to chair the next YNiC ASC session? If so, send an
email to the ynic-users stating the topic for discussion, and the date
on which you would like to hold the session. I look forward to hearing
from you all ...
thanks,
Michael
--
Dr Michael Simpson
Science Liaison Officer
York Neuroimaging Centre
Innovation Way
York
YO10 5DG
Tel: 01904 567614
Web: http://www.ynic.york.ac.uk
Hi, all,
This is just a reminder that tomorrow (Thursday) at 4PM, MSC students
will be giving presentations at YNiC.
Everyone is welcome
Silvia Gennari
Department of Psychology
University of York
York, YO10 5DD
United Kingdom
Dear All
I will attempt to chair a discussion this Wednesday (11th) at 4pm on
virtual electrode analysis in MEG. The meeting is the first of the
proposed YNiC Analysis Support Colloquia looking at current and
future needs for data analysis (MRI as well as MEG). The meeting
will take place in the Psychology
lecture theatre (B020), NOT in YNiC.
Virtual electrode analyses probe individual points in the brain.
They potentially allow you to chart the response at that location
over time, taking full advantage of the capacity of MEG to record
changes over time with millisecond accuracy. Some of us feel,
possibly naively, that the ability to do virtual electrode analyses
at a group as well as an individual level is all that stands between
us and world domination.
Piers will begin by demonstrating some group level analyses that he
and colleagues have done as part of an MEG study that included
written words, consonant strings and faces as stimuli. The aim of
the session, however, is not to discuss the meaning of different
studies, but what what forms of virtual electrode analysis are
possible, and what we could hope to learn from them.
If you have attempted any virtual electrode analyses, or think that
you may want to do some in future, please bring them along. Anyone
who has any results to share is welcome to bring along some slides.
So that's Wednesday at 4pm in Psychology B020.
Andy
--
Professor Andy Ellis
Department of Psychology
University of York
York YO10 5DD
England
Tel. +44 (0)1904 433140
http://www.york.ac.uk/depts/psych/www/people/biogs/awe1.html
Dear all,
This is just to confirm that Andy Ellis will be chairing the first YNiC
Analysis Support Colloquia on Wednesday February 13th. The session will
take place in B020 at 4pm.
Andy will forward an agenda in due course which will detail the specific
questions he will raise in the session. However, following his previous
mailing to ynic-users, the general topic of the session will be Virtual
Electrode Analysis of MEG data.
We look forward to seeing you there. Here's hoping for a good turnout at
the inaugural session of what we hope will be a mutually beneficial
series of colloquia.
Thanks,
Michael
--
Dr Michael Simpson
Science Liaison Officer
York Neuroimaging Centre
Innovation Way
York
YO10 5DG
Tel: 01904 567614
Web: http://www.ynic.york.ac.uk
Dear all,
this is just a reminder that the MEG masterclass will take place
tomorrow. A number of you contacted Andre at the start of the
masterclasses to let him know that you are likely to attend these
sessions. If you haven't previously let him know of your interest for
the MEG class, and would like to attend, please contact *me* so that we
can have a rough idea of numbers.
The session will take place from 2.30 till 5.00 in Open Plan.
Thanks,
Michael
--
Dr Michael Simpson
Science Liaison Officer
York Neuroimaging Centre
Innovation Way
York
YO10 5DG
Tel: 01904 567614
Web: http://www.ynic.york.ac.uk
----------------------------
Plastic bags and paper work have been left on the bed in the MRI corridor.
Please ensure that your projects are aware that this is a clinical area
and needs to remain clean and tidy.
Will you please also remind students that any scrubs worn need to be put
in the laundry bin.
Thank you
Dear All,
I am copying Claire's message to all users, so that everyone is aware of
the need to keep the MRI corridor clear of debris.
Thanks
Tony
---------------------------- Original Message ----------------------------
Subject: [Staff] MRI corridor
From: "Claire Fox" <claire.fox(a)ynic.york.ac.uk>
Date: Thu, January 31, 2008 10:06 am
To: staff(a)ynic.york.ac.uk
--------------------------------------------------------------------------
Plastic bags and paper work have been left on the bed in the corridor.
Please ensure that your projects are aware that this is a clinical area
and needs to remain clean and tidy.
Will you please also remind students that any scrubs worn need to be put
in the laundry bin.
Thank you
Claire
_______________________________________________
Staff mailing list
Staff(a)ynic.york.ac.uk
https://www.ynic.york.ac.uk/mailman/listinfo/staff
I would like to re-iterate (see my previous email of 21/01/08):
"MSc students with timetable commitment that prevent them attending the
masterclasses should be aware that it is our intention to run a separate
session(s) for the MSc program. (Date to be confirmed)."
Sylvia - we are happy to liaise with you on this.
************************************************************************
Andre Gouws
User Support Manager
York Neuroimaging Centre
The Biocentre
York Science Park
Heslington
YO10 5DG
Tel: +44 (0) 1904 435328
Fax: +44 (0) 1904 435356