- ynic-users

20 Jan '11

Dear Users Today (4.30-5.30 pm YNiC open plan) Andy Ellis will give a talk on "Semantically-driven re-activation of visual cortex in object recognition?". Summary: Magnetoencephalography was used to probe the nature and time course of responses to early and late acquired objects in a covert naming task. Analysis focused on regions in left occipital and anterior temporal cortex that have been reported to show stronger responses to early than late acquired objects in fMRI. An evoked response in visual cortex around 170 ms was followed by an evoked response in anterior temporal cortex (150-250 ms) that was stronger to early than late acquired objects. This was followed by an induced re-activation of visual cortex from 250 ms onwards that was also modulated by age of acquisition. The talk will illustrate one way of making statistical comparisons across experimental conditions in MEG. Everyone is welcome to attend. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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change in start time of YNiC seminars
by rem 19 Jan '11

19 Jan '11

Dear Users Please be aware that, as of this week, YNiC Thursday seminars will start at the later time of *4.30 pm*. This shift in the starting time is necessary to avoid a clash with teaching sessions in Psychology. Thank you Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminar 20th January
by rem 17 Jan '11

17 Jan '11

Dear Users This week (4-5 pm YNiC open plan) Andy Ellis will give a talk on "Semantically-driven re-activation of visual cortex in object recognition?". Summary: Magnetoencephalography was used to probe the nature and time course of responses to early and late acquired objects in a covert naming task. Analysis focused on regions in left occipital and anterior temporal cortex that have been reported to show stronger responses to early than late acquired objects in fMRI. An evoked response in visual cortex around 170 ms was followed by an evoked response in anterior temporal cortex (150-250 ms) that was stronger to early than late acquired objects. This was followed by an induced re-activation of visual cortex from 250 ms onwards that was also modulated by age of acquisition. Everyone is welcome to attend. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminar today
by rem 13 Jan '11

13 Jan '11

Dear Users Today (4-5 pm YNiC open plan) Chris Racey will give a project proposal talk on "Processing of real world objects in object selective cortex: effects of parametric manipulation of size change". Summary: The visual system is able to perform recognition tasks in a manner that appears to be invariant to changes in size of the retinal image. It is thought that this size invariance is established early on in visual processing (Goodale & Milner, 1992; Rolls, 2000). The aim of the present study is to measure adaptation to objects of changing size across the whole visual system and across several size change conditions which vary parametrically. The design of the present experiment will be an fMR-adaptation paradigm similar to that used in our previous work looking at viewpoint invariance (Racey et al., 2010). We aim to measure differences in size invariance for objects between the various category selective brain regions at the level of the Ventral Occipito-Temporal cortex (VOT). Further, we aim to measure the change in size invariance moving posterior to anterior through the visual processing hierarchy. Everyone is welcome to attend. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminar 13th January
by rem 10 Jan '11

10 Jan '11

Dear Users This week (4-5 pm YNiC open plan) Chris Racey will give a project proposal talk on "Processing of real world objects in object selective cortex: effects of parametric manipulation of size change". Summary: The visual system is able to perform recognition tasks in a manner that appears to be invariant to changes in size of the retinal image. It is thought that this size invariance is established early on in visual processing (Goodale & Milner, 1992; Rolls, 2000). The aim of the present study is to measure adaptation to objects of changing size across the whole visual system and across several size change conditions which vary parametrically. The design of the present experiment will be an fMR-adaptation paradigm similar to that used in our previous work looking at viewpoint invariance (Racey et al., 2010). We aim to measure differences in size invariance for objects between the various category selective brain regions at the level of the Ventral Occipito-Temporal cortex (VOT). Further, we aim to measure the change in size invariance moving posterior to anterior through the visual processing hierarchy. Everyone is welcome to attend. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC Security code change
by Jo Saunders 06 Jan '11

06 Jan '11

The security access code for YNiC has been changed today. So if any user has a set of access door keys for YNiC, and hasn't already been advised of the new access code, then could they please contact myself or another member of YNiC staff. This change has no impact on the door fobs which should continue to work as before. Many thanks, Jo. -- ............................ Jo Saunders Centre Manager YNiC The BioCentre York Science Park YORK YO10 5DG Email: Joanna(a)ynic.york.ac.uk Tel: (01904) 435343 Fax: (01904) 435356 Tues, Wed & Thurs .............................

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MRI operation
by Gary Green 13 Dec '10

13 Dec '10

Dear Colleagues As you know, Alliance Medical have now left YNiC. This means that they obviously are not providing MRI Operators. The only authorised MRI operators are Andre Gouws Mark Hymers Ross Devlin (temporary appointment to cover clinical projects, but is available for research scanning from the 5th of January) others are in training. I will inform you when more operators become available Please do not try and operate the magnet console if you are not on the list. This is for your safety and those of your participants. You will not be covered by insurance if an incident were to occur. The full list of operators can always be found at https://www.ynic.york.ac.uk/information/mri-operators Gary -- Gary Green York Neuroimaging Centre The Biocentre York Science Park Innovation Way Heslington York YO10 5DG http://www.ynic.york.ac.uk https://www.ynic.york.ac.uk/about-us/people/ggrg tel. +44 (0) 1904 435349 PA (Amy Gibson) +44 (0) 1904 435329 or amy.gibson(a)ynic.york.ac.uk fax +44 (0) 1904 435356 mobile +44 (0) 788 191 3004

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YNiC seminar today
by rem 09 Dec '10

09 Dec '10

Dear Users Today (4-5 pm in YNiC open plan) Gary Green will give a talk on ""Opportunities for pattern classifiers". Everyone is welcome to attend and refreshments will be available afterwards. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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Downtime at YNiC
by Mark Hymers 06 Dec '10

06 Dec '10

Hi, As you are probably aware, YNiC open plan will be closed tomorrow for staff training. We're also going to take the opportunity to perform a needed hardware fix on one of the main servers, so it won't be possible for people to leave analyses running on the machines in open plan or the cluster. This outage will be from around 9am for an hour or so. This will also affect the remote desktop service, which will be rebooted as part of the work - anybody who has suspended sessions should make sure that they save their work before tomorrow morning. I've explicitly Bcc'd those who appear to have sessions running to ensure that they know about this - apologies to anyone who gets the mail twice. Thanks, Mark -- Mark Hymers York Neuroimaging Centre

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YNiC seminar 9th December
by rem 06 Dec '10

06 Dec '10

Dear Users This week (4-5 pm in YNiC open plan) Gary Green will give a talk on ""Opportunities for pattern classifiers". Everyone is welcome to attend and refreshments will be available afterwards. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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[Fwd: VSS Abstract Submission Deadline is this Wednesday, December 1st]
by Tim Andrews 30 Nov '10

30 Nov '10

Dear All, The deadline for abstracts to VSS is Wednesday, December 1st (11:59 latest time zone on earth). This might be Thursday morning for us! Tim -------- Original Message -------- Subject: VSS Abstract Submission Deadline is this Wednesday, December 1st Date: Mon, 29 Nov 2010 17:04:47 -0800 From: Vision Sciences Society <VSS(a)visionsciences.org> Reply-To: VSS Information <vss(a)visionsciences.org> To: t.andrews(a)psych.york.ac.uk The deadline for submitting abstracts for the VSS 2011 Meeting is Wednesday, December 1st (11:59 latest time zone on earth). To access your online account, log in to the VSS Online Membership and Meeting System <http://www.visionsciences1.org/vss_public/>. You must renew your membership for 2011 to be eligible to submit an abstract. For more information or if you have questions, please contact Vision Sciences Society <mailto:vss@visionsciences.org>. If you are applying for the 2011 Elsevier/Vision Research Travel Award all supporting documentation is also due on 12/1/10. Complete application instructions can be found at Student Travel Awards <http://www.visionsciences.org/awards.html>. Follow Us on Twitter <http://twitter.com/VSSMtg> <http://www.facebook.com/pages/Vision-Sciences-Society-Official-VSS-Page/355…> -- Dr Tim Andrews Department of Psychology University of York York, YO10 5DD UK Tel: 44-1904-434356 Fax: 44-1904-433181 http://www-users.york.ac.uk/~ta505/

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no YNiC seminar this week
by rem 29 Nov '10

29 Nov '10

Dear Users There will not be a YNiC seminar this Thursday (2nd December). The next seminar will be given by Gary Green on 9th December. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminar today 4pm
by Andre Gouws 25 Nov '10

25 Nov '10

Dear Users This afternoon Andre Gouws will be giving a presentation (4-5 pm) in YNiC open plan. The title of Andre's talk is "Suppressive feedback from the visual cortex to the LGN: Evidence from negative BOLD". This presentation will include results and discussion of data presented at SFN this year, and will conclude with a project presentation for extension of the current work. Everyone is welcome to attend and refreshments will be available afterwards. -- ynic-users mailing list ynic-users(a)ynic.york.ac.uk https://www.ynic.york.ac.uk/mailman/listinfo/ynic-users ************************************************************************ Andre Gouws York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 435327 Fax: +44 (0) 1904 435356

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MSc Teaching in YNiC open plan
by Sam Johnson 24 Nov '10

24 Nov '10

Hello all, Just a reminder that tomorrow from 1:15 to 3:15 YNiC open plan will be full with another practical for the masters students. Anyone wanting to come up early for the seminar would be advised to not come up too early. Thanks, Sam -- Sam Johnson Science Manager, York NeuroImaging Centre University of York http://www.ynic.york.ac.uk

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IMPORTANT CHANGES - fMRI SCANNING.
by Andre Gouws 22 Nov '10

22 Nov '10

Hi all, IF YOU USE PRESENTATION IN fMRI PLEASE READ THIS! We have recently been experiencing issues with the synchronisation of stimulus code in Presentation with pulses from the scanner. This problem has been intermittent and inconsistent. As many scans rely on precise timings by synch-ing with specific pulses from the scanner, we have had to come up with an alternate solution. Without boring you with the fine detail, we are using a different port on the scanner to provide us with the pulse information. After extensive testing this afternoon, this port seems to give consistent output while the other does not. Anyone using pulses from the scanner to synchronise their presentation stimuli should note the following: Change "pulses_per_scan" in your scenario header (.sce files) to the actual number of slices you are acquiring. In the past this has been set to half the number (e.g. if you were acquiring 38 slices per TR you had pulses_per_scan = 19). Just to make that clear, YOU SHOULD DOUBLE THE NUMBER YOU CURRENTLY HAVE IN pulses_per_scan. N.B. YOU MUST CHANGE THESE NUMBERS WITH IMMEDIATE EFFECT OR YOUR TIMINGS WILL BE INCORRECT. Also note that when you run your pulses calibration scan you will now get twice the number of pulses you got before. This will not affect your data in any way, it simply means that you are getting a pulse for every slice from the scanner, rather than every second slice. This will work for all TRs, and the back room settings should now be the same for all researchers. If you have any queries, please contact me. Andre' -- Andre' ************************************************************************ Andre Gouws York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 435327 Fax: +44 (0) 1904 435356

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YNiC seminar 25th November
by Andre Gouws 22 Nov '10

22 Nov '10

Dear Users This week Andre Gouws will be giving a presentation on Thursday afternoon (4-5 pm) in YNiC open plan. The title of Andre's talk is "Suppressive feedback from the visual cortex to the LGN: Evidence from negative BOLD". This presentation will include results and discussion of data presented at SFN this year, and will conclude with a project presentation for extension of the current work. Everyone is welcome to attend and refreshments will be available afterwards. -- ynic-users mailing list ynic-users(a)ynic.york.ac.uk https://www.ynic.york.ac.uk/mailman/listinfo/ynic-users ************************************************************************ Andre Gouws York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 435327 Fax: +44 (0) 1904 435356

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YNiC Open plan closed - Tues 7th Dec 2010
by Jo Saunders 18 Nov '10

18 Nov '10

Dear Users, just to let you know that due to staff training on the 7th December 2010 the YNiC Open Plan area will be closed to all users on that date between 9am and 4pm. MRI scanning will be continuing as usual. Apologies for any inconvenience that this may cause. Thanks and regards, Jo. -- ............................ Jo Saunders Centre Manager YNiC The BioCentre York Science Park YORK YO10 5DG Email: Joanna(a)ynic.york.ac.uk Tel: (01904) 435343 Fax: (01904) 435356 Tues, Wed & Thurs .............................

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YNiC seminar today
by Rebecca E Millman 18 Nov '10

18 Nov '10

Dear Users Today (starting at 4 pm) Beth Jefferies from the Department of Psychology will give a talk on "TMS studies of semantic cognition". In this talk, Beth will discuss recent studies examining the extended neural networks underpinning semantic representation and control, talk about the new equipment that is in the YNiC TMS lab, and describe a planned study which combines TMS and fMRI to investigate how this brain network responds to stimulation. Everyone is welcome to attend. Best wishes Rebecca -- Dr. Rebecca E. Millman York Neuroimaging Centre The Biocentre York Science Park York YO10 5DG Email: rem(a)ynic.york.ac.uk Tel: 01904 435 5373

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YNiC seminar 18th November
by rem 15 Nov '10

15 Nov '10

Dear Users This week (4-5 pm) Beth Jefferies from the Department of Psychology will give a talk on "TMS studies of semantic cognition". In this talk, Beth will discuss recent studies examining the extended neural networks underpinning semantic representation and control, talk about the new equipment that is in the YNiC TMS lab, and describe a planned study which combines TMS and fMRI to investigate how this brain network responds to stimulation. Everyone is welcome to attend. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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MSc session in open plan
by Sam Johnson 11 Nov '10

11 Nov '10

Hello all, Just a reminder that between 13:15 and 15:15 YNiC open plan will be pretty much full with the MSc practical, so again, if you were planning to come up before the seminars you'd be much better off waiting till they've finished. Thanks, Sam -- Sam Johnson Science Manager, York NeuroImaging Centre University of York http://www.ynic.york.ac.uk

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seminars today
by Gary Green 11 Nov '10

11 Nov '10

The notice about this afternoon's seminars said that the talks are project presentations. In fact they are presentations about current research in Aberdeen and are part of on-going discussions about potential collaboration between York and Aberdeen. Gary -- Gary Green York Neuroimaging Centre The Biocentre York Science Park Innovation Way Heslington York YO10 5DG http://www.ynic.york.ac.uk https://www.ynic.york.ac.uk/about-us/people/ggrg tel. +44 (0) 1904 435349 PA (Claire Fox) +44 (0) 1904 435329 fax +44 (0) 1904 435356 mobile +44 (0) 788 191 3004

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YNiC seminar today
by rem 11 Nov '10

11 Nov '10

Dear Users Today from 4-5 pm in YNiC open plan there will be 3 project proposal presentations: i) Prof. David Lurie "Field-Cycling Magnetic Resonance Imaging" Contrast between normal and diseased tissue in MRI arises mainly from differences in relaxation times. It is also well known from in vitro studies that the variation of T1 with field strength (T1 dispersion) changes from tissue to tissue, and may also be altered in disease. Thus, it is potentially useful to be able to measure T1 dispersion in vivo; however, this information cannot be obtained by conventional MRI scanners, which operate at fixed magnetic field. We are developing field-cycling MRI systems, in which the magnetic field is switched rapidly between levels during the pulse sequence, always returning to the same field for signal measurement. FC-MRI offers the possibility of new image contrast mechanisms based on T1 dispersion. In particular, immobilised proteins give rise to "quadrupole dips" in the dispersion curve, and this mechanism may give insight into the behaviour (and misbehaviour) of proteins in disease. This talk will discuss the methodology, technology and applications of FC-MRI. ii) Prof. Thomas Redpath "Dynamic contrast-enhanced MRI in breast cancer". My talk will cover the basic physiology underlying dynamic contrast-enhanced MRI, the scanning methods used, and will describe the pharmaco-kinetic models used in analysing the signal versus time curves which are seen in breast cancers. The need for arterial input functions in the newer models will be discussed and a novel approach which we have proposed will be outlined. The particular problem of scanning at 3 tesla, namely RF pulse angle variation across the body, and methods of overcoming it will also be covered. iii) Dr. Hugh Seton "Ultra-low field MRI with cooled receiver coils and SQUID preamplifiers" "The presentation will describe MRI developments at 10-20mT. Imaging at such low fields has the potential to deliver improved contrast compared to high field, partly because T1 differences between tissues can increase at low field but also because there is greater flexibility to employ contrast-enhancing pulse sequences which would exceed RF power deposition limits at high field. Normally the SNR is poor at low field, but we have developed cooled receiver coils and ultra-low noise SQUID preamplifiers that yield 3-6 fold SNR gains compared to conventional room temperature coils." Everyone is welcome to attend and refreshments will be available afterwards. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminar today
by rem 10 Nov '10

10 Nov '10

Dear Users Today from 4-5 pm in YNiC open plan, Susanne Weis and Markus Hausmann will be giving YNiC project proposal presentations. i) Susanne Weis: "Object location memory: Differences between verbal and non-verbal strategies during memory encoding and retrieval" It has repeatedly been shown that the medial temporal lobe (MTL), and especially the hippocampus, play an important role during memory encoding and retrieval. Specifically,activation of the hippocampus has been related to associative and contextual memory and binding of an item with its context. It is therefore assumed, that the hippocampus interacts with cortical regions during object location memory (OLM) tasks, where an object has to be bound to its spatial location. A variety of studies have shown that men on average perform better than women in specific aspects of spatial cognition. On the other hand, women have been shown to be superior in OLM tasks. One explanation which has been proposed for this findings suggests that women use verbal strategies during OLM encoding and retrieval, while man rely more on spatial strategies. It can be assumed that different strategies during OLM task are linked to different patterns of brain activation. It is the aim of our study to examine functional connectivity between the hippocampus and cortical areas during encoding and retrieval of an OLM task. Further, we intend to find out if inter-individual differences in strategies result in changes of patterns of brain activation and the functional connectivity within these networks. ii) Markus Hausmann: "Sex hormonal effects on the functional connectivity within and across hemispheres in postmenopausal women" Previous research in postmenopausal women has shown that hormone therapy (HT), and estrogen therapy (ET) in particular, affects the functional brain organization such as interhemispheric integration and functional cerebral asymmetries (FCAs) (Bayer & Erdmann, 2008; Bayer & Hausmann, 2009a,b; Bayer & Hausmann, 2010). The results suggest that these effects are mediated by the neuromodulatory properties of estradiol on intrahemispheric functional networks. Specifically, it seems that estradiol enhances verbal processing at the expense of visuo-spatial processing within the right hemisphere. This idea might explain why several studies found divergent effects of HT on verbal and visuo-spatial cognition (including verbal and non-verbal memory). Moreover, estradiol-related effects on FCAs have also been demonstrated in normally cycling women during hormonal distinct cycle-phases (Weis et al., 2008). Specifically, this fMRI study found estradiol-related changes in the interhemispheric inhibition between homotopic areas in the inferior frontal gyrus of the left and right hemispheres. The present study is set out to elucidate whether HT-related changes in FCAs as measured by a verbal and visuo-spatial visual half-field tasks in postmenopausal women might be subserved by changes in the functional connectivity between cortical networks within and across hemispheres. Everyone is welcome to attend. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminars this week
by rem 08 Nov '10

08 Nov '10

Dear Users Please note that there will be two YNiC seminars this week; one at the usual time on Thursday and an additional seminar on Wednesday afternoon. On Wednesday Dr. Susanne Weis and Dr. Markus Hausmann, from the University of Durham, will give project proposal presentations from 4-5 pm: Dr. Susanne Weis: "Object location memory: Differences between verbal and non-verbal strategies during memory encoding and retrieval" Dr. Markus Hausmann: ""Sex hormonal effects on the functional connectivity within and across hemispheres in postmenopausal women" On Thursday there will be 3 project proposal presentations by Prof. David Lurie, Prof. Thomas Redpath and Dr. Hugh Seton from the University of Aberdeen: Prof. David Lurie: ""Field-Cycling Magnetic Resonance Imaging" Prof. Thomas Redpath: "Dynamic contrast-enhanced MRI in breast cancer" Dr. Hugh Seton: "Ultra-low field MRI with cooled receiver coils and SQUID preamplifiers" Please see below for further information about each talk. Everyone is welcome to attend and refreshments will be available afterwards. Best wishes Rebecca *1) Wednesday 10th November * i) Susanne Weis "Object location memory: Differences between verbal and non-verbal strategies during memory encoding and retrieval" It has repeatedly been shown that the medial temporal lobe (MTL), and especially the hippocampus, play an important role during memory encoding and retrieval. Specifically,activation of the hippocampus has been related to associative and contextual memory and binding of an item with its context. It is therefore assumed, that the hippocampus interacts with cortical regions during object location memory (OLM) tasks, where an object has to be bound to its spatial location. A variety of studies have shown that men on average perform better than women in specific aspects of spatial cognition. On the other hand, women have been shown to be superior in OLM tasks. One explanation which has been proposed for this findings suggests that women use verbal strategies during OLM encoding and retrieval, while man rely more on spatial strategies. It can be assumed that different strategies during OLM task are linked to different patterns of brain activation. It is the aim of our study to examine functional connectivity between the hippocampus and cortical areas during encoding and retrieval of an OLM task. Further, we intend to find out if inter-individual differences in strategies result in changes of patterns of brain activation and the functional connectivity within these networks. ii) Markus Hausmann "Sex hormonal effects on the functional connectivity within and across hemispheres in postmenopausal women" Previous research in postmenopausal women has shown that hormone therapy (HT), and estrogen therapy (ET) in particular, affects the functional brain organization such as interhemispheric integration and functional cerebral asymmetries (FCAs) (Bayer & Erdmann, 2008; Bayer & Hausmann, 2009a,b; Bayer & Hausmann, 2010). The results suggest that these effects are mediated by the neuromodulatory properties of estradiol on intrahemispheric functional networks. Specifically, it seems that estradiol enhances verbal processing at the expense of visuo-spatial processing within the right hemisphere. This idea might explain why several studies found divergent effects of HT on verbal and visuo-spatial cognition (including verbal and non-verbal memory). Moreover, estradiol-related effects on FCAs have also been demonstrated in normally cycling women during hormonal distinct cycle-phases (Weis et al., 2008). Specifically, this fMRI study found estradiol-related changes in the interhemispheric inhibition between homotopic areas in the inferior frontal gyrus of the left and right hemispheres. The present study is set out to elucidate whether HT-related changes in FCAs as measured by a verbal and visuo-spatial visual half-field tasks in postmenopausal women might be subserved by changes in the functional connectivity between cortical networks within and across hemispheres. *2) Thursday 11th November * i) Prof. David Lurie "Field-Cycling Magnetic Resonance Imaging" Contrast between normal and diseased tissue in MRI arises mainly from differences in relaxation times. It is also well known from in vitro studies that the variation of T1 with field strength (T1 dispersion) changes from tissue to tissue, and may also be altered in disease. Thus, it is potentially useful to be able to measure T1 dispersion in vivo; however, this information cannot be obtained by conventional MRI scanners, which operate at fixed magnetic field. We are developing field-cycling MRI systems, in which the magnetic field is switched rapidly between levels during the pulse sequence, always returning to the same field for signal measurement. FC-MRI offers the possibility of new image contrast mechanisms based on T1 dispersion. In particular, immobilised proteins give rise to "quadrupole dips" in the dispersion curve, and this mechanism may give insight into the behaviour (and misbehaviour) of proteins in disease. This talk will discuss the methodology, technology and applications of FC-MRI. ii) Prof. Thomas Redpath "Dynamic contrast-enhanced MRI in breast cancer". My talk will cover the basic physiology underlying dynamic contrast-enhanced MRI, the scanning methods used, and will describe the pharmaco-kinetic models used in analysing the signal versus time curves which are seen in breast cancers. The need for arterial input functions in the newer models will be discussed and a novel approach which we have proposed will be outlined. The particular problem of scanning at 3 tesla, namely RF pulse angle variation across the body, and methods of overcoming it will also be covered. iii) Dr. Hugh Seton "Ultra-low field MRI with cooled receiver coils and SQUID preamplifiers" "The presentation will describe MRI developments at 10-20mT. Imaging at such low fields has the potential to deliver improved contrast compared to high field, partly because T1 differences between tissues can increase at low field but also because there is greater flexibility to employ contrast-enhancing pulse sequences which would exceed RF power deposition limits at high field. Normally the SNR is poor at low field, but we have developed cooled receiver coils and ultra-low noise SQUID preamplifiers that yield 3-6 fold SNR gains compared to conventional room temperature coils." -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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Neuroscience Job in Italy
by Silke Goebel 05 Nov '10

05 Nov '10

*Assistant or Associate Research Professors, Center for Mind/Brain Sciences, Trento * The Center for Mind/Brain Sciences (CIMeC) at the University of Trento is seeking to fill a number of research positions in cognitive neuroscience at the Assistant or Associate Research Professor level. The Center offers an international and vibrant research setting in which to investigate the functioning of the brain through the analysis of its functional, structural and physiological characteristics, in both normal and pathological states. Researchers at the Center make use of state-of-the-art neuroimaging methodologies, including a research-only MRI scanner, MEG, EEG and TMS, as well as behavioral, eye tracking and motion tracking laboratories. The Center also includes a neuropsychology and neuro-rehabilitation clinic (CERiN). The Center strongly encourages collaborative and innovative research, and provides the opportunity for all researchers to access laboratory resources and to be part of the Doctoral School in Cognitive and Brain Sciences. CIMeC also has close collaborations with local research centers, including FBK (Fondazione Bruno Kessler) and IIT (Italian Institute of Technology), through joint projects and through the doctoral school. Further information about the Center can be found at: http://www.cimec.unitn.it <http://www.cimec.unitn.it/>. The ideal researchers (from all areas of cognitive neuroscience, including computational neuroscience and neuroimaging methods) must hold the Ph.D. or M.D. degree, and should have a record documenting research creativity, independence, and productivity. We are looking for researchers able to build and maintain a high quality research program and to contribute to the maintenance of a collegial and collaborative academic environment. For more information see attachment. -- Dr Silke Goebel Department of Psychology University of York Heslington York YO10 5DD UK Tel: +44 (0) 1904 32 2872 Email: s.goebel(a)psych.york.ac.uk Web: http://www.york.ac.uk/res/crl/sgoebel.html TMS Lab: http://www.york.ac.uk/res/tms EMAIL DISCLAIMER http://www.york.ac.uk/docs/disclaimer/email.htm

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