- ynic-users

YNiC seminar 27th October
by rem 24 Oct '11

24 Oct '11

Dear Users This Thursday (4.15-5.15 pm in YNiC) I will be giving a talk on ""Representations of the temporal envelope of sounds in human auditory cortex: Comparing results from non-invasive MEG "virtual electrodes" and invasive intracortical electrode recordings". Magnetoencephalography (MEG) is a non-invasive neuroimaging technique that provides direct measurements of neural activity with a millisecond temporal resolution. An important application of MEG "virtual electrode" analyses is linking non-invasive MEG measurements and invasive electrophysiological recordings in animals (e.g. Zumer et al., 2010) and humans (e.g. Hall et al., 2005; Dalal et al., 2008, 2009). In this talk I will present results from a study that used non-invasive MEG "virtual electrodes" to try to replicate the results from an invasive intracortical electrode study (Nourski et al., 2009) on the mechanisms for encoding the temporal envelope of speech in human auditory cortex. Everyone is welcome to attend and refreshments will be provided after the talk. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminar today
by rem 20 Oct '11

20 Oct '11

Dear Users Today (4-5 pm in YNiC) there will be a project proposal presentation by Mark Hymers. The title of the project is "The functional organisation of the recognition of speech and music". Please see below for the talk abstract. Everyone is welcome to attend and refreshments will be provided after the talk. Best wishes Rebecca ****************************************************************** Mark Hymers and Rebecca Millman Abstract: There is debate in the literature over the extent to which speech and music perception recruits shared computational systems (e.g. Patel, 2003; Peretz and Zatorre, 2005; Fedorenko et al., 2009; Rogalsky et al., 2011). The proposed study will use functional Magnetic Resonance Imaging (fMRI) and “perceptual pop-out” to determine the neural basis of both speech and music recognition. Perceptual pop-out is achieved by presenting a degraded/distorted musical or speech sound that appears meaningless when heard for the first time but is easily recognisable after hearing an undegraded/undistorted version of the same sound. Perceptual pop-put has been used in previous studies of speech recognition (e.g. Liebenthal et al., 2003; Giraud et al., 2004; Möttönen et al., 2006) but not, to our knowledge, in studies of melody recognition. In this study we will take advantage of the effect of perceptual pop-out for both music (known melodies) and speech (IEEE sentences) stimuli to control for acoustical differences in the musical and speech stimuli. This approach will allow us to determine the extent of organisational overlap in the representation of music and speech recognition within the same group of participants. -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC business
by Sam Johnson 18 Oct '11

18 Oct '11

Hello all, It's that time of year again, when the latest horde of master students descend. Thursday afternoons for the rest of this term will be very busy in the open plan area of YNiC. There won't be any free machines, and any machines logged in will be logged out, so from about 1-3:30 you shouldn't plan to be using the desktops in YNiC. Apologies for any inconvenience. Thanks, Sam -- Sam Johnson Science Manager, York NeuroImaging Centre University of York http://www.ynic.york.ac.uk

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YNiC seminar this week
by rem 17 Oct '11

17 Oct '11

Dear Users This Thursday (4-5 pm in YNiC) there will be a project proposal presentation by Mark Hymers. The title of the project is "The functional organisation of the recognition of speech and music". Please see below for the talk abstract. Everyone is welcome to attend and refreshments will be provided after the talk. Best wishes Rebecca ****************************************************************** Mark Hymers and Rebecca Millman Abstract: There is debate in the literature over the extent to which speech and music perception recruits shared computational systems (e.g. Patel, 2003; Peretz and Zatorre, 2005; Fedorenko et al., 2009; Rogalsky et al., 2011). The proposed study will use functional Magnetic Resonance Imaging (fMRI) and “perceptual pop-out” to determine the neural basis of both speech and music recognition. Perceptual pop-out is achieved by presenting a degraded/distorted musical or speech sound that appears meaningless when heard for the first time but is easily recognisable after hearing an undegraded/undistorted version of the same sound. Perceptual pop-put has been used in previous studies of speech recognition (e.g. Liebenthal et al., 2003; Giraud et al., 2004; Möttönen et al., 2006) but not, to our knowledge, in studies of melody recognition. In this study we will take advantage of the effect of perceptual pop-out for both music (known melodies) and speech (IEEE sentences) stimuli to control for acoustical differences in the musical and speech stimuli. This approach will allow us to determine the extent of organisational overlap in the representation of music and speech recognition within the same group of participants. -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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Fwd:Postdoc positions in Glasgow
by Gary Green 14 Oct '11

14 Oct '11

FYI ------------------------ Joint Advert Positions M00447 & M00448 The Institute of Neuroscience and Psychology at University of Glasgow opens two post-doctoral research associate positions, starting on January 1st, 2012 for 2 years, to contribute to two projects: a BBSRC-funded project âAudio-visual integration of identity information from the face and voice: a combined behavioural, fMRI and MEG studyâ; an MRC-funded project âLifelong changes in the cerebral processing of social signalsâ. The successful candidates will have a Ph.D. or equivalent and a minimum of 5 years research experience, with normally 1-2 years relevant post-doctoral experience; extensive and up-to-date practical and theoretical knowledge in fMRI, MEG and/or EEG experimentation; excellent knowledge of experimental procedures in the cognitive neurosciences and of experimental statistics, and excellent knowledge of Matlab and experimental control software. Informal enquiries to: Prof Pascal Belin pascal.belin(a)glasgow.ac.uk. Tel: +44(0)141 330 4629; Prof Joachim Gross Joachim.Gross(a)glasgow.ac.uk. Tel: +44(0)141 330 3947; Dr Marie-HÃ©lÃ¨ne Grosbras marie.grosbras@ glasgow.ac.uk. Tel: +44(0)141 330 5264; Dr Guillaume Rousselet guillaume.rousselet@ glasgow.ac.uk. Tel: +44(0)141 330 6652. Apply online at www.glasgow.ac.uk/jobs

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Fwd: [megcommunity] Senior Lecturer or Associate Professor in Neuroscience (MEG)
by Gary Green 13 Oct '11

13 Oct '11

FYI -------- Original Message -------- The Brain & Psychological Sciences Research Centre (BPsyC) at Swinburne University, Melbourne, Australia, is seeking candidates for a Senior Lecturer or Associate Professor in Neuroscience (MEG). The Centre has recently taken possession of an Elekta Triux MEG scanner, to complement the existing Siemens 3T Trio MRI, TMS and EEG facilities, and is seeking to expand the existing MEG expertise within the team. The position will have the following principal roles: (i) developing, conducting and advancing research with a focus on magnetoencephalography (MEG), particularly its clinical applications; (ii) providing consultation in cognate teaching areas, and (iii) contributing to administration within the centre under the direction on the Centre Director and Executive Committee. Applicants must hold a PhD in a relevant subject along with a strong track record of peer reviewed publications and success in attracting competitive external funding. International applicants will receive relocation support. For further details please see http://tinyurl.com/3jk24kj Closing date for applications is 30th October 2011. For those not familiar with Melbourne, it recently came top in a survey of the world's best cities in which to live. From the Wall Street Journal - 'Straddling the Yarra River, Melbourne boasts a European-style cafe culture of hidden coffee spots and restaurants as well as a passion for sport, including an annual Formula One grand prix, cricket, rugby and homegrown Aussie rules football.' -- Will Woods Brain and Psychological Sciences Research Centre Faculty of Life and Social Sciences Swinburne University of Technology P.O Box 218 Hawthorn, VIC, 3122 Australia Phone:(61 3) 9214 5946 Fax: (61 3) 9214 5525

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YNiC seminars this term
by rem 10 Oct '11

10 Oct '11

Dear YNiC Users The list of forthcoming YNiC seminars can be found here: https://www.ynic.york.ac.uk/events/thursday-sessions As usual I will send reminder emails each week on Monday and Thursday. Please note that there will not be a seminar this week because it is Induction Week. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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Interesting new explanation for why fMRI scanners cause dizziness.
by Chris Racey 04 Oct '11

04 Oct '11

This might be important for anyone planning on doing eye tracking in the scanner because the described process causes abnormal eye movements... http://www.sciencedirect.com/science/article/pii/S0960982211009353 Chris

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PS
by philip quinlan 30 Sep '11

30 Sep '11

PS. I should add that before you get carried away with the recent 'advice' by Nieuwenhuis et al. (2011, Nature Neuroscience) consult VIckers and Altman (2001)! ******************************************************************** Philip Quinlan E-Mail: ptq1(a)york.ac.uk Department of Psychology FAX: (01904) 323181 The University of York Tel: (01904) 320000 Ext. 3135 Heslington Direct : (01904) 323135 York YO10 5DD U.K. ********************************************************************

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Downtime for upgrade
by Mark Hymers 29 Sep '11

29 Sep '11

Hi, Just a final reminder that tomorrow morning starting at around 9am, the YNiC desktop, cluster and remote desktop systems will be undergoing upgrade work. We expect this to be complete by lunchtime, with the exception of the remote desktop service which may be out of action until next week. Thanks, Mark -- Mark Hymers York Neuroimaging Centre

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Fwd: [megcommunity] MSc/PhD Positions at Dalhousie University
by Gary Green 29 Sep '11

29 Sep '11

FYI ------------------ We are recruiting MSc and PhD students for a funded MEG study looking at neuronal connectivity and stroke recovery. Students will have the opportunity to undergo research through the Depts of Kinesiology or Psychology/Neuroscience at Dalhousie University in Halifax, Nova Scotia, Canada. This research project will capitalize on the spatiotemporal resolution of MEG to examine changes in connectivity within the sensorimotor network of individuals post-stroke. Specifically, the goal of this research is to ‘pave the road to post-stroke rehabilitation’. Identifying the ‘normal’ sensorimotor network and establishing the relationship between network re-organization and functional recovery will permit the development and implementation of treatments to direct brain recovery. With regard to the proposed research project, and in groups of non-disabled controls and patients post-stroke, our objectives include: 1. To establish the connectivity pattern of the ‘normal’ sensorimotor network and demonstrate the ability to detect changes within the network using an established motor learning paradigm 2. Using clinical measures of upper limb function, we will establish the relationship between the pattern of sensorimotor network connectivity and functional recovery in well and poorly recovered patients You can find more information at: http://myweb.dal.ca/sh539856/ If interested, please e-mail Dr. Shaun Boe (s.boe(a)dal.ca <mailto:s.boe@dal.ca>) or Dr. Tim Bardouille (tim.bardouille(a)nrc.ca <mailto:tim.bardouille@nrc.ca>). Best, Tim Bardouille. --------------------------------------------------------- Timothy Bardouille, PhD, Research Officer Laboratory for Clinical MEG NRC Institute for Biodiagnostics (Atlantic) Office: Halifax Infirmary 3900 - 1796 Summer Street Halifax, Nova Scotia B3H 3A7 Phone: 902-473-1865 Lab: 902-470-3936 Fax: 902-473-1851 ---------------------------------------------------------

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Fwd: [Eeglabnews] EEGLAB 10.2.5.5 now available - critical upgrade
by Gary Green 26 Sep '11

26 Sep '11

FYI These changes may be important if you are using EEGLAB for multiple subject analyses Gary -------- Original Message -------- Subject: [Eeglabnews] EEGLAB 10.2.5.5 now available - critical upgrade Date: Tue, 13 Sep 2011 09:43:48 +0200 From: Arnaud Delorme <arno(a)ucsd.edu> To: eeglabnews(a)sccn.ucsd.edu Dear EEGLAB users, New EEGLAB version 10.2.5.5 is now available. This is a critical update if you are using EEGLAB STUDY sets to process multiple subjects. This version fixes 3 important problems: - Plotting ERP and power spectral scalp topographies (a problem that appeared in EEGLAB 10.2.2.4 two months ago). You will not need to recompute anything. - Plotting ERSP data (for independent component clusters and channels) when a common baseline is being subtracted from the data (not the default option). You will not need to recompute anything. - Correctly computing component cluster ERSPs when independent components were selected using a residual variance threshold. Simply download the latest version of EEGLAB 10; upon opening a STUDY, a warning message will appear if you need to recompute ERSPs. EEGLAB 9.0.8.6 has also been updated. The list of all recent changes are available at: http://sccn.ucsd.edu/wiki/EEGLAB_revision_history We are constantly working on new test scripts to attempt to validate outputs for complex STUDY structures. Whenever you encounter a problem, please submit a bug report at http://sccn.ucsd.edu/eeglab/bugzilla. <http://sccn.ucsd.edu/eeglab/bugzilla> Thank you for using EEGLAB, A. Delorme

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Help with mri analysis
by philip quinlan 19 Sep '11

19 Sep '11

I have two related but different tasks - task A and task B. I find that when you do task A regions x, y, z light up and when you do task B regions x, y, z, and w light up. As we all know all regions of the brain light up to varying degrees regardless what's going on but what I want to be able to demonstrate is that w really is a region unique to task B. I should add the data for tasks A and B were collected under different conditions so no simple 'contrast' is possible. Any help gratefully received. Philip. ******************************************************************** Philip Quinlan E-Mail: ptq1(a)york.ac.uk Department of Psychology FAX: (01904) 323181 The University of York Tel: (01904) 320000 Ext. 3135 Heslington Direct : (01904) 323135 York YO10 5DD U.K. ********************************************************************

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YNiC Desktop and Cluster Upgrade
by Mark Hymers 09 Sep '11

09 Sep '11

Hi, On Friday 23rd September, we'll be upgrading the YNiC desktops and cluster machines to a new software release. The main changes are: * FSL 3.3 will no longer be available * FSL 4.1.4 will be upgraded to FSL 4.1.8 * The default Matlab version will move to 7.12 * python2.5 will move to python2.6 (2.5 will still be available but some modules may be missing) Unsupported software changes: * afni will be updated from 20101222 -> 20110610 * freesurfer 4.5 will no longer be available; 5.1 will be available instead (although possibly not immediately, we'll announce this at the time) This means that on the morning of Friday 23rd, there will be some disruption at YNiC and the remote desktop service will be unavailable. It is possible that the remote desktop service will remain unavailable for a couple of days after the migration in order to give us extra time to migrate it, although we are aiming to avoid this. Thanks, Mark -- Mark Hymers York Neuroimaging Centre

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[Fwd: [megcommunity] MEG research position]
by Gary Green 06 Sep '11

06 Sep '11

FYI Research assistant, Pittsburgh, Pennsylvania, USA ________________________________________ Employment Type: Full-time 24-month appointment as a Research Assistant Institution: Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA Available: September 1, 2011 Job description: A research assistant position is available with the UPMC MEG Brain Mapping Center (http://www.meg-brain-mapping.pitt.edu/index.html) at the University of Pittsburgh Medical Center in Pittsburgh, PA. The research will consist of using MEG to study the temporal dynamics of how brain regions interact, both in spontaneously (when people are at rest) and in the service of visual processing. Candidates will be expected to: • Analyze MEG data using advanced mathematical and computational methods some of which have been developed in house primarily using MATLAB • Assist in data collection from healthy volunteers and clinical groups • Assist in the preparation of manuscripts • Work independently and liaise between collaborating laboratories Qualifications: • Undergraduate or Masters degree in Psychology, Neuroscience, Mathematics, Physics, Computer Science, Mathematics, Engineering or related field • Strong organizational skills • Previous experience in computer programming (MATLAB experience preferred) • Previous experience in image/signal processing would be highly advantageous • Prior experience in neuroimaging data analysis would be a plus • Prior experience in working with clinical groups would be a plus Salary: Commensurate with Experience How to Apply: If interested, please send a CV, cover letter, and names of references to Dr. Avniel Ghuman, Department of Neurological Surgery, University of Pittsburgh Medical Center at ghumana(a)cnbc.cmu.edu. Applications will be considered until the position is filled. -- Gary Green

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YNiC Reception move
by Reception 30 Aug '11

30 Aug '11

Dear YNiC Users, preparations for the construction of the new Centre for Hyperpolarisation (CHyM) are scheduled to start with the next week, with the build anticipated to last for about 10 months. During the course of the building work the YNiC entrance doors will not be in use and all users and visitors are therefore requested to access YNiC via the main BioCentre reception doors. During the course of the works Claire and I will be in the temporary YNiC reception office which can be found to the left hand side of the BioCentre reception desk. Our contact details will remain the same. The participant forms will not be moved to the temporary office so anyone needing access to these is requested to see any member of YNiC staff for assistance. Please continue to drop off participant forms in the post box. Further updates about the progress of the building work will be issued in due course and a display including the building plans can be found in the BioCentre foyer area. With best wishes, Jo. -- ............................ Jo Saunders Centre Manager YNiC The BioCentre York Science Park YORK YO10 5DG Email: Joanna(a)ynic.york.ac.uk Tel: (01904) 435343 Fax: (01904) 435356 Tues, Wed & Thurs .............................

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PhD research studentship
by gm654＠york.ac.uk 29 Aug '11

29 Aug '11

Dear All, please find below the announcement for a PhD studentship in the University of Milano-Bicocca. Regards, Giulia University of Milano-Bicocca, Department of Psychology Four-year Ph.D. Research Studentship Deadline: October 10th, 2011 A fully-funded Ph.D. studentship beginning in January 2012 for 4 years is available within the Doctoral School in Psychology and Cognitive Science, Department of Psychology at University of Milano-Bicocca, Milano, Italy, for applicants interested in the study of cognitive functions (language, verbal STM, executive functions) in neuropsychological patients and in unimpaired subjects by means of TMS, tDCS and fMRI. Also research on deaf and deafblind individuals is currently performed. These are topics available in the Doctoral Training Program in "Experimental Psychology, Linguistic and Cognitive Neuroscience", which has available a total of six 4-year full time studentships. Two summer schools will be also organized. The successful applicant will have access to all the facilities available within the TMS-EEG (and EMG) lab at the Department of Psychology, as well as Eye-Trackers, ERP, fMRI (the latter within a Hospital nearby the University), neurosurgery patients undergoing awake surgery for tumor removal and neuropsychological patients in several different hospitals in MIlano. We encourage application from candidates with a demonstrable interest in working with patients or with experience on the different methodologies. Applications are welcome from UK and EU as well as non-EU citizens. Candidates should have, or expect to get, an undergraduate degree in Psychology or a related discipline. A Master degree in psychological research methods or a cognate discipline would be an advantage. Funding will consist of a monthly salary of approximately 1,170 Euros plus support for travel and equipment. The deadline for application is October 10th, 2011. Selection will take place in the form of a written test and oral colloquium in October. Information about how to apply can be found at the following links: - italian version: http://www.unimib.it/open/news/Bando-XXVII-ciclo-corsi-di-Dottorato-condeco… - english version: courtesy english translation: http://www.unimib.it/open/news/Announcements-englishversion/824598639538508… "Announcement for courses that will begin on 1st January 2012" (page 15 of the .pdf file). Enquires about how to apply can be e-mailed to the following address: phdpsineco(a)unimib.it Please, feel free to contact prof. Costanza Papagno with questions. Dipartimento di Psicologia Università di Milano-Bicocca e-mail: costanza.papagno(a)unimib.it Skype: costanza1411 Please feel free to pass this information on to any interested undergraduate or master student you may know.

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YNiC seminar today (external speaker)
by rem 24 Aug '11

24 Aug '11

Dear Users Today (4-5 pm in YNiC) there will be a talk by Dr. Peter van Zijl from Johns Hopkins University and the Kennedy Krieger Institute. http://www.kennedykrieger.org/kki_staff.jsp?pid=1064 The title of Dr van Zijl's talk is "Chemical Exchange Saturation Transfer (CEST) contrast agents". Please see below for the talk abstract. Everyone is welcome to attend and refreshments will be provided after the talk. Best wishes Rebecca Abstract: CEST agents1,2 exploit exchangeable protons to achieve contrast in MRI. This can be accomplished by using radiofrequency saturation at the NMR frequency of these protons and monitoring of the transfer of this saturation to the water protons imaged in MRI. When continuous saturation is applied, strong sensitivity enhancements (factors of hundred to hundreds of thousands depending on the protons) can be attained to image micromolar compounds. CEST agents have been broadly classified in terms of containing paramagnetic metals (paraCEST) or not (diaCEST). The main characteristic of diaCEST agents is that the chemical shift range of their exchangeable protons is limited to a range of approximately 6-7 ppm positive with respect to the water signal, which can be extended by another 6-7 ppm through hydrogen bonding of the exchangeable site. Currently, protons used for diaCEST include OH (hydroxyl, ~0-3ppm from water), NH2 (amine ~0-3 ppm from water), NH (amide, ~3- 4ppm from water; imino, ~5-7ppm from water). The main compounds are carbohydrates (sugars), peptides and proteins, and nucleic acids, which is important to mention because these are natural bio-organic substances. MRI is an insensitive method and, contrary to PET and optical approaches, the application of contrast agents often requires physiologically incompatible (micromolar-millimolar) concentrations. Unlike paramagnetic metallic contrast agents, diaCEST provides natural, non-metallic labels. As a consequence, this methodology has already allowed the use of many agents in vivo in animals, while endogenous markers such as cellular peptides and sugar derivatives are even been studied in humans. Recent data suggest that amide proton transfer (APT) may provide a biomarker for separating tumor recurrence from treatment necrosis in the brain. ^3 In this presentation, an overview will be given of current diaCEST agents as well as of their applications and pitfalls. Based on its non-invasive character, diaCEST is expected to revolutionize the rapid translation of contrast agents to the clinic. The field is evolving rapidly and many novel exogenous agents and endogenous markers are expected to be discovered in the near future. Reference: 1) Ward KM et al. J Magn Reson 2000;143:79–87. 2) van Zijl PC, Yadav NN. Magn Reson Med. 2011;65(4):927-48. 3) Zhou J. et al. Nat Med. 2011;17(1):130-4. -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminar 24th August
by rem 22 Aug '11

22 Aug '11

Dear Users This *Wednesday* (4-5 pm in YNiC) there will be a talk by Dr. Peter van Zijl from Johns Hopkins University and the Kennedy Krieger Institute. http://www.kennedykrieger.org/kki_staff.jsp?pid=1064 The title of Dr van Zijl's talk is "Chemical Exchange Saturation Transfer (CEST) contrast agents". Please see below for the talk abstract. Everyone is welcome to attend and refreshments will be provided after the talk. Best wishes Rebecca Abstract: CEST agents^1,2 exploit exchangeable protons to achieve contrast in MRI. This can be accomplished by using radiofrequency saturation at the NMR frequency of these protons and monitoring of the transfer of this saturation to the water protons imaged in MRI. When continuous saturation is applied, strong sensitivity enhancements (factors of hundred to hundreds of thousands depending on the protons) can be attained to image micromolar compounds. CEST agents have been broadly classified in terms of containing paramagnetic metals (paraCEST) or not (diaCEST). The main characteristic of diaCEST agents is that the chemical shift range of their exchangeable protons is limited to a range of approximately 6-7 ppm positive with respect to the water signal, which can be extended by another 6-7 ppm through hydrogen bonding of the exchangeable site. Currently, protons used for diaCEST include OH (hydroxyl, ~0-3ppm from water), NH2 (amine ~0-3 ppm from water), NH (amide, ~3- 4ppm from water; imino, ~5-7ppm from water). The main compounds are carbohydrates (sugars), peptides and proteins, and nucleic acids, which is important to mention because these are natural bio-organic substances. MRI is an insensitive method and, contrary to PET and optical approaches, the application of contrast agents often requires physiologically incompatible (micromolar-millimolar) concentrations. Unlike paramagnetic metallic contrast agents, diaCEST provides natural, non-metallic labels. As a consequence, this methodology has already allowed the use of many agents in vivo in animals, while endogenous markers such as cellular peptides and sugar derivatives are even been studied in humans. Recent data suggest that amide proton transfer (APT) may provide a biomarker for separating tumor recurrence from treatment necrosis in the brain. ^3 In this presentation, an overview will be given of current diaCEST agents as well as of their applications and pitfalls. Based on its non-invasive character, diaCEST is expected to revolutionize the rapid translation of contrast agents to the clinic. The field is evolving rapidly and many novel exogenous agents and endogenous markers are expected to be discovered in the near future. Reference: 1) Ward KM et al. J Magn Reson 2000;143:79–87. 2) van Zijl PC, Yadav NN. Magn Reson Med. 2011;65(4):927-48. 3) Zhou J. et al. Nat Med. 2011;17(1):130-4. -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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[Fwd: [megcommunity] MEG related positions at the Donders Institute/Nijmegen]
by Gary Green 15 Aug '11

15 Aug '11

FYI --------------------- Dear all, I would like to point your attention to the following MEG related positions at the Donders Institute, Nijmegen, The Netherlands. PhD position: cueing in Parkinson’s disease http://www.umcn.nl/OverUMCstRadboud/werkenbij/Pages/Vacature.aspx?VacatureN… PhD position: Bridging the Gap between Neuronal Activity and Neuroimaging http://www.ru.nl/donders/jobs/vm/vacancies/ Post doctoral fellow in sensorimotor neuroscience http://www.umcn.nl/OverUMCstRadboud/werkenbij/Pages/Vacature.aspx?VacatureN… *** <http://www.ru.nl/publish/pages/605682/phd_position_30_08_111.pdf>*** All the best, Ole -- Ole Jensen http://www.neuosc.com -- Gary Green York Neuroimaging Centre The Biocentre York Science Park Innovation Way Heslington York YO10 5DG http://www.ynic.york.ac.uk https://www.ynic.york.ac.uk/about-us/people/ggrg tel. +44 (0) 1904 435349 PA - Claire Fox : +44 (0) 1904 435329 or Claire.Fox(a)ynic.york.ac.uk fax +44 (0) 1904 435356 mobile +44 (0) 788 191 3004

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YNiC seminar today (external speaker)
by rem 11 Aug '11

11 Aug '11

Dear Users Today (4-5 pm in YNiC) there will be a talk by Dr Aneurin Kennerley from the University of Sheffield. http://www.sheffield.ac.uk/psychology/staff/research/aneurin-kennerley The title of Dr Kennerley's talk is "Concurrent 7T fMRI and 2-D Optical Imaging Spectroscopy: Towards building a forward model between neuronal activity and the BOLD signal". Please see below for the talk abstract. Everyone is welcome to attend and refreshments will be provided after the talk. Best wishes Rebecca Abstract: Functional magnetic resonance imaging (fMRI) has become the cornerstone of cognitive neuroscience in recent years. The widely used Blood Oxygenation Level Dependent (BOLD) signal is often used to interpret changes in neuronal activation. However, at present, a biophysical understanding of the neurovascular drivers of the BOLD signal is not clear and thus hinders any quantitative estimation of the underlying neuronal activity. Neuroimaging research at the University of Sheffield drives towards building a forward biophysical model of this complex relationship. As part of this multidisciplinary group my research is aimed at developing a general model of the BOLD signal which can model both intra- and extra- vascular MR signals, across a wide range of imaging parameters, from estimates of the haemodynamic changes. Validation and refinement of the haemodynamic response models underlying fMRI signals, an essential precondition for the correct interpretation of human BOLD data requires invasive multimodal animal imaging. I have developed an innovative in-vivo methodology for concurrent fMRI and 2D optical imaging spectroscopy (2D-OIS) techniques for simultaneous measurement of BOLD signal and underlying haemoglobin changes to neuronal activation in the healthy rodent model. Applications of this technology include: 1) Understanding of the negative BOLD signal (Boorman et al 2010). Most researchers assume a negative BOLD to be a result of either neuronal inhibition or vascular steal. It is only with the simultaneous, independent measurement of haemoglobin changes (with 2D-OIS) that one could disassociate any possible physiological relationships; 2) Refinement of mathematical and biophysical models of both the BOLD signal and optical imaging spectroscopy techniques (Kennerley et.al. 2009); 3) Calibration of non-BOLD fMRI techniques such as VASO and ASL; 4) Interpretation of abnormal BOLD responses; specifically in disease and trauma conditions in which either neuronal or haemodynamic breakdown could be responsible. [1] Boorman, L.W. et.al. (2010) /Journal of Neuroscience/. /30(12): 4285-94;/ [2] Kennerley, A.J. et.al (2009) /NeuroImage 47:1608-1619/; -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminar 11th August (external speaker)
by rem 08 Aug '11

08 Aug '11

Dear Users This Thursday (4-5 pm in YNiC) there will be a talk by Dr Aneurin Kennerley from the University of Sheffield. http://www.sheffield.ac.uk/psychology/staff/research/aneurin-kennerley The title of Dr Kennerley's talk is "Concurrent 7T fMRI and 2-D Optical Imaging Spectroscopy: Towards building a forward model between neuronal activity and the BOLD signal". Please see below for the talk abstract. Everyone is welcome to attend and refreshments will be provided after the talk. Best wishes Rebecca Abstract: Functional magnetic resonance imaging (fMRI) has become the cornerstone of cognitive neuroscience in recent years. The widely used Blood Oxygenation Level Dependent (BOLD) signal is often used to interpret changes in neuronal activation. However, at present, a biophysical understanding of the neurovascular drivers of the BOLD signal is not clear and thus hinders any quantitative estimation of the underlying neuronal activity. Neuroimaging research at the University of Sheffield drives towards building a forward biophysical model of this complex relationship. As part of this multidisciplinary group my research is aimed at developing a general model of the BOLD signal which can model both intra- and extra- vascular MR signals, across a wide range of imaging parameters, from estimates of the haemodynamic changes. Validation and refinement of the haemodynamic response models underlying fMRI signals, an essential precondition for the correct interpretation of human BOLD data requires invasive multimodal animal imaging. I have developed an innovative in-vivo methodology for concurrent fMRI and 2D optical imaging spectroscopy (2D-OIS) techniques for simultaneous measurement of BOLD signal and underlying haemoglobin changes to neuronal activation in the healthy rodent model. Applications of this technology include: 1) Understanding of the negative BOLD signal (Boorman et al 2010). Most researchers assume a negative BOLD to be a result of either neuronal inhibition or vascular steal. It is only with the simultaneous, independent measurement of haemoglobin changes (with 2D-OIS) that one could disassociate any possible physiological relationships; 2) Refinement of mathematical and biophysical models of both the BOLD signal and optical imaging spectroscopy techniques (Kennerley et.al. 2009); 3) Calibration of non-BOLD fMRI techniques such as VASO and ASL; 4) Interpretation of abnormal BOLD responses; specifically in disease and trauma conditions in which either neuronal or haemodynamic breakdown could be responsible. [1] Boorman, L.W. et.al. (2010) /Journal of Neuroscience/. /30(12): 4285-94;/ [2] Kennerley, A.J. et.al (2009) /NeuroImage 47:1608-1619/; -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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[Fwd: [Eeglabnews] EEGLAB multiple subject channel interpolation bug]
by Claire Fox (secretary for Gary Green) 05 Aug '11

05 Aug '11

Some users may need to be aware of this particular bug in EEG. -- Claire Fox PA to Professor Gary Green The York Neuroimaging Centre Innovation Way Science Park York YO10 5DG Tel: 01904 435329 Fax: 01904 435356 Email: Claire.fox(a)ynic.york.ac.uk

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[Fwd: [megcommunity] Invitation to contribute to a Special Issue on Brain Oscillations during Language Processing]
by Gary Green 02 Aug '11

02 Aug '11

FYI --------------------------------------- Dear colleagues, We would like to invite you to contribute your research to our special issue on the role of brain oscillations in language processing, to appear in Frontiers in Language Science. You can visit the web site at: _http://www.frontiersin.org/languagesciences/specialtopics/brain_oscillatio… See detailed description below. The call has been very successful so far and prominent figures in the field have joined us in this project. We are looking forward to receiving your research. Best wishes, Lucia Melloni & Marcela Pena *Brain Oscillations during Language Processing: from Perception to Production * /Deadline for abstract submission: 01 Sep 2011 / /Deadline for full article submission: 15 Dec 2011 / Language processing is a seemingly effortless task that requires the integration of speech units (e.g., phonemes, syllables, words, etc.) occurring at different rates. In particular, temporal binding for speech should occur within and across different temporal scales, necessitating multiple simultaneous windows of integration for prosodic, semantic, syntactic and pragmatic processing. Recent evidence suggests that neuronal oscillations may reflect both tracking linguistic units at their individual rhythms as well as integrating speech units over a large range of temporal scales. The present Research Topic would like to evaluate current theories and evidence for a mechanistic role of neuronal oscillations in measuring language processing, covering the latest advances brought about by EEG, MEG and fMRI imaging methods. Our main focus is to highlight innovative and foundational studies that go beyond methodological issues and advance our theoretical understanding of the role of brain oscillations in language processing. Contributions from the pioneers of this field are selected, illustrating how the study of brain oscillations has allowed investigating theoretically relevant questions that could not be addressed by more traditional methods. The topic thus aims at deepening our mechanistic understanding of language processing and bringing us closer to bridging the gap between brain, mind and behavior for the crucial cognitive function of speech. Hosted By: Marcela Pena <http://www.frontiersin.org/people/MarcelaPena/5634>, Catholic University of Chile, Chile Lucia Melloni <http://www.frontiersin.org/people/LuciaMelloni/32689>, Max Planck Institute for Brain Research, Germany ------------------------------ Lucia Melloni, Ph.D Max Planck Institute for Brain Research Deutschordenstr. 46 60528 Frankfurt am Main Germany lucia.melloni(a)brain.mpg.de <mailto:lucia.melloni@brain.mpg.de> T: +49 69 96769-268 <tel:%2B49%2069%2096769-268> F: +49 69 96769-327 <tel:%2B49%2069%2096769-327> -- Gary Green

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HBM Review Presentation
by michael＠ynic.york.ac.uk 28 Jul '11

28 Jul '11

Dear all, for the few of you who wanted to follow up some of the references from my talk today, I've put the presentation here: /groups/resources/hbmReview.pptx Some of the videos probably won't work, so I've added links to where they may be accessed. Michael

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