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YNiC Open plan closed - Tues 7th Dec 2010
by Jo Saunders 18 Nov '10

18 Nov '10

Dear Users, just to let you know that due to staff training on the 7th December 2010 the YNiC Open Plan area will be closed to all users on that date between 9am and 4pm. MRI scanning will be continuing as usual. Apologies for any inconvenience that this may cause. Thanks and regards, Jo. -- ............................ Jo Saunders Centre Manager YNiC The BioCentre York Science Park YORK YO10 5DG Email: Joanna(a)ynic.york.ac.uk Tel: (01904) 435343 Fax: (01904) 435356 Tues, Wed & Thurs .............................

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YNiC seminar today
by Rebecca E Millman 18 Nov '10

18 Nov '10

Dear Users Today (starting at 4 pm) Beth Jefferies from the Department of Psychology will give a talk on "TMS studies of semantic cognition". In this talk, Beth will discuss recent studies examining the extended neural networks underpinning semantic representation and control, talk about the new equipment that is in the YNiC TMS lab, and describe a planned study which combines TMS and fMRI to investigate how this brain network responds to stimulation. Everyone is welcome to attend. Best wishes Rebecca -- Dr. Rebecca E. Millman York Neuroimaging Centre The Biocentre York Science Park York YO10 5DG Email: rem(a)ynic.york.ac.uk Tel: 01904 435 5373

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YNiC seminar 18th November
by rem 15 Nov '10

15 Nov '10

Dear Users This week (4-5 pm) Beth Jefferies from the Department of Psychology will give a talk on "TMS studies of semantic cognition". In this talk, Beth will discuss recent studies examining the extended neural networks underpinning semantic representation and control, talk about the new equipment that is in the YNiC TMS lab, and describe a planned study which combines TMS and fMRI to investigate how this brain network responds to stimulation. Everyone is welcome to attend. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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MSc session in open plan
by Sam Johnson 11 Nov '10

11 Nov '10

Hello all, Just a reminder that between 13:15 and 15:15 YNiC open plan will be pretty much full with the MSc practical, so again, if you were planning to come up before the seminars you'd be much better off waiting till they've finished. Thanks, Sam -- Sam Johnson Science Manager, York NeuroImaging Centre University of York http://www.ynic.york.ac.uk

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seminars today
by Gary Green 11 Nov '10

11 Nov '10

The notice about this afternoon's seminars said that the talks are project presentations. In fact they are presentations about current research in Aberdeen and are part of on-going discussions about potential collaboration between York and Aberdeen. Gary -- Gary Green York Neuroimaging Centre The Biocentre York Science Park Innovation Way Heslington York YO10 5DG http://www.ynic.york.ac.uk https://www.ynic.york.ac.uk/about-us/people/ggrg tel. +44 (0) 1904 435349 PA (Claire Fox) +44 (0) 1904 435329 fax +44 (0) 1904 435356 mobile +44 (0) 788 191 3004

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YNiC seminar today
by rem 11 Nov '10

11 Nov '10

Dear Users Today from 4-5 pm in YNiC open plan there will be 3 project proposal presentations: i) Prof. David Lurie "Field-Cycling Magnetic Resonance Imaging" Contrast between normal and diseased tissue in MRI arises mainly from differences in relaxation times. It is also well known from in vitro studies that the variation of T1 with field strength (T1 dispersion) changes from tissue to tissue, and may also be altered in disease. Thus, it is potentially useful to be able to measure T1 dispersion in vivo; however, this information cannot be obtained by conventional MRI scanners, which operate at fixed magnetic field. We are developing field-cycling MRI systems, in which the magnetic field is switched rapidly between levels during the pulse sequence, always returning to the same field for signal measurement. FC-MRI offers the possibility of new image contrast mechanisms based on T1 dispersion. In particular, immobilised proteins give rise to "quadrupole dips" in the dispersion curve, and this mechanism may give insight into the behaviour (and misbehaviour) of proteins in disease. This talk will discuss the methodology, technology and applications of FC-MRI. ii) Prof. Thomas Redpath "Dynamic contrast-enhanced MRI in breast cancer". My talk will cover the basic physiology underlying dynamic contrast-enhanced MRI, the scanning methods used, and will describe the pharmaco-kinetic models used in analysing the signal versus time curves which are seen in breast cancers. The need for arterial input functions in the newer models will be discussed and a novel approach which we have proposed will be outlined. The particular problem of scanning at 3 tesla, namely RF pulse angle variation across the body, and methods of overcoming it will also be covered. iii) Dr. Hugh Seton "Ultra-low field MRI with cooled receiver coils and SQUID preamplifiers" "The presentation will describe MRI developments at 10-20mT. Imaging at such low fields has the potential to deliver improved contrast compared to high field, partly because T1 differences between tissues can increase at low field but also because there is greater flexibility to employ contrast-enhancing pulse sequences which would exceed RF power deposition limits at high field. Normally the SNR is poor at low field, but we have developed cooled receiver coils and ultra-low noise SQUID preamplifiers that yield 3-6 fold SNR gains compared to conventional room temperature coils." Everyone is welcome to attend and refreshments will be available afterwards. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminar today
by rem 10 Nov '10

10 Nov '10

Dear Users Today from 4-5 pm in YNiC open plan, Susanne Weis and Markus Hausmann will be giving YNiC project proposal presentations. i) Susanne Weis: "Object location memory: Differences between verbal and non-verbal strategies during memory encoding and retrieval" It has repeatedly been shown that the medial temporal lobe (MTL), and especially the hippocampus, play an important role during memory encoding and retrieval. Specifically,activation of the hippocampus has been related to associative and contextual memory and binding of an item with its context. It is therefore assumed, that the hippocampus interacts with cortical regions during object location memory (OLM) tasks, where an object has to be bound to its spatial location. A variety of studies have shown that men on average perform better than women in specific aspects of spatial cognition. On the other hand, women have been shown to be superior in OLM tasks. One explanation which has been proposed for this findings suggests that women use verbal strategies during OLM encoding and retrieval, while man rely more on spatial strategies. It can be assumed that different strategies during OLM task are linked to different patterns of brain activation. It is the aim of our study to examine functional connectivity between the hippocampus and cortical areas during encoding and retrieval of an OLM task. Further, we intend to find out if inter-individual differences in strategies result in changes of patterns of brain activation and the functional connectivity within these networks. ii) Markus Hausmann: "Sex hormonal effects on the functional connectivity within and across hemispheres in postmenopausal women" Previous research in postmenopausal women has shown that hormone therapy (HT), and estrogen therapy (ET) in particular, affects the functional brain organization such as interhemispheric integration and functional cerebral asymmetries (FCAs) (Bayer & Erdmann, 2008; Bayer & Hausmann, 2009a,b; Bayer & Hausmann, 2010). The results suggest that these effects are mediated by the neuromodulatory properties of estradiol on intrahemispheric functional networks. Specifically, it seems that estradiol enhances verbal processing at the expense of visuo-spatial processing within the right hemisphere. This idea might explain why several studies found divergent effects of HT on verbal and visuo-spatial cognition (including verbal and non-verbal memory). Moreover, estradiol-related effects on FCAs have also been demonstrated in normally cycling women during hormonal distinct cycle-phases (Weis et al., 2008). Specifically, this fMRI study found estradiol-related changes in the interhemispheric inhibition between homotopic areas in the inferior frontal gyrus of the left and right hemispheres. The present study is set out to elucidate whether HT-related changes in FCAs as measured by a verbal and visuo-spatial visual half-field tasks in postmenopausal women might be subserved by changes in the functional connectivity between cortical networks within and across hemispheres. Everyone is welcome to attend. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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YNiC seminars this week
by rem 08 Nov '10

08 Nov '10

Dear Users Please note that there will be two YNiC seminars this week; one at the usual time on Thursday and an additional seminar on Wednesday afternoon. On Wednesday Dr. Susanne Weis and Dr. Markus Hausmann, from the University of Durham, will give project proposal presentations from 4-5 pm: Dr. Susanne Weis: "Object location memory: Differences between verbal and non-verbal strategies during memory encoding and retrieval" Dr. Markus Hausmann: ""Sex hormonal effects on the functional connectivity within and across hemispheres in postmenopausal women" On Thursday there will be 3 project proposal presentations by Prof. David Lurie, Prof. Thomas Redpath and Dr. Hugh Seton from the University of Aberdeen: Prof. David Lurie: ""Field-Cycling Magnetic Resonance Imaging" Prof. Thomas Redpath: "Dynamic contrast-enhanced MRI in breast cancer" Dr. Hugh Seton: "Ultra-low field MRI with cooled receiver coils and SQUID preamplifiers" Please see below for further information about each talk. Everyone is welcome to attend and refreshments will be available afterwards. Best wishes Rebecca *1) Wednesday 10th November * i) Susanne Weis "Object location memory: Differences between verbal and non-verbal strategies during memory encoding and retrieval" It has repeatedly been shown that the medial temporal lobe (MTL), and especially the hippocampus, play an important role during memory encoding and retrieval. Specifically,activation of the hippocampus has been related to associative and contextual memory and binding of an item with its context. It is therefore assumed, that the hippocampus interacts with cortical regions during object location memory (OLM) tasks, where an object has to be bound to its spatial location. A variety of studies have shown that men on average perform better than women in specific aspects of spatial cognition. On the other hand, women have been shown to be superior in OLM tasks. One explanation which has been proposed for this findings suggests that women use verbal strategies during OLM encoding and retrieval, while man rely more on spatial strategies. It can be assumed that different strategies during OLM task are linked to different patterns of brain activation. It is the aim of our study to examine functional connectivity between the hippocampus and cortical areas during encoding and retrieval of an OLM task. Further, we intend to find out if inter-individual differences in strategies result in changes of patterns of brain activation and the functional connectivity within these networks. ii) Markus Hausmann "Sex hormonal effects on the functional connectivity within and across hemispheres in postmenopausal women" Previous research in postmenopausal women has shown that hormone therapy (HT), and estrogen therapy (ET) in particular, affects the functional brain organization such as interhemispheric integration and functional cerebral asymmetries (FCAs) (Bayer & Erdmann, 2008; Bayer & Hausmann, 2009a,b; Bayer & Hausmann, 2010). The results suggest that these effects are mediated by the neuromodulatory properties of estradiol on intrahemispheric functional networks. Specifically, it seems that estradiol enhances verbal processing at the expense of visuo-spatial processing within the right hemisphere. This idea might explain why several studies found divergent effects of HT on verbal and visuo-spatial cognition (including verbal and non-verbal memory). Moreover, estradiol-related effects on FCAs have also been demonstrated in normally cycling women during hormonal distinct cycle-phases (Weis et al., 2008). Specifically, this fMRI study found estradiol-related changes in the interhemispheric inhibition between homotopic areas in the inferior frontal gyrus of the left and right hemispheres. The present study is set out to elucidate whether HT-related changes in FCAs as measured by a verbal and visuo-spatial visual half-field tasks in postmenopausal women might be subserved by changes in the functional connectivity between cortical networks within and across hemispheres. *2) Thursday 11th November * i) Prof. David Lurie "Field-Cycling Magnetic Resonance Imaging" Contrast between normal and diseased tissue in MRI arises mainly from differences in relaxation times. It is also well known from in vitro studies that the variation of T1 with field strength (T1 dispersion) changes from tissue to tissue, and may also be altered in disease. Thus, it is potentially useful to be able to measure T1 dispersion in vivo; however, this information cannot be obtained by conventional MRI scanners, which operate at fixed magnetic field. We are developing field-cycling MRI systems, in which the magnetic field is switched rapidly between levels during the pulse sequence, always returning to the same field for signal measurement. FC-MRI offers the possibility of new image contrast mechanisms based on T1 dispersion. In particular, immobilised proteins give rise to "quadrupole dips" in the dispersion curve, and this mechanism may give insight into the behaviour (and misbehaviour) of proteins in disease. This talk will discuss the methodology, technology and applications of FC-MRI. ii) Prof. Thomas Redpath "Dynamic contrast-enhanced MRI in breast cancer". My talk will cover the basic physiology underlying dynamic contrast-enhanced MRI, the scanning methods used, and will describe the pharmaco-kinetic models used in analysing the signal versus time curves which are seen in breast cancers. The need for arterial input functions in the newer models will be discussed and a novel approach which we have proposed will be outlined. The particular problem of scanning at 3 tesla, namely RF pulse angle variation across the body, and methods of overcoming it will also be covered. iii) Dr. Hugh Seton "Ultra-low field MRI with cooled receiver coils and SQUID preamplifiers" "The presentation will describe MRI developments at 10-20mT. Imaging at such low fields has the potential to deliver improved contrast compared to high field, partly because T1 differences between tissues can increase at low field but also because there is greater flexibility to employ contrast-enhancing pulse sequences which would exceed RF power deposition limits at high field. Normally the SNR is poor at low field, but we have developed cooled receiver coils and ultra-low noise SQUID preamplifiers that yield 3-6 fold SNR gains compared to conventional room temperature coils." -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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Neuroscience Job in Italy
by Silke Goebel 05 Nov '10

05 Nov '10

*Assistant or Associate Research Professors, Center for Mind/Brain Sciences, Trento * The Center for Mind/Brain Sciences (CIMeC) at the University of Trento is seeking to fill a number of research positions in cognitive neuroscience at the Assistant or Associate Research Professor level. The Center offers an international and vibrant research setting in which to investigate the functioning of the brain through the analysis of its functional, structural and physiological characteristics, in both normal and pathological states. Researchers at the Center make use of state-of-the-art neuroimaging methodologies, including a research-only MRI scanner, MEG, EEG and TMS, as well as behavioral, eye tracking and motion tracking laboratories. The Center also includes a neuropsychology and neuro-rehabilitation clinic (CERiN). The Center strongly encourages collaborative and innovative research, and provides the opportunity for all researchers to access laboratory resources and to be part of the Doctoral School in Cognitive and Brain Sciences. CIMeC also has close collaborations with local research centers, including FBK (Fondazione Bruno Kessler) and IIT (Italian Institute of Technology), through joint projects and through the doctoral school. Further information about the Center can be found at: http://www.cimec.unitn.it <http://www.cimec.unitn.it/>. The ideal researchers (from all areas of cognitive neuroscience, including computational neuroscience and neuroimaging methods) must hold the Ph.D. or M.D. degree, and should have a record documenting research creativity, independence, and productivity. We are looking for researchers able to build and maintain a high quality research program and to contribute to the maintenance of a collegial and collaborative academic environment. For more information see attachment. -- Dr Silke Goebel Department of Psychology University of York Heslington York YO10 5DD UK Tel: +44 (0) 1904 32 2872 Email: s.goebel(a)psych.york.ac.uk Web: http://www.york.ac.uk/res/crl/sgoebel.html TMS Lab: http://www.york.ac.uk/res/tms EMAIL DISCLAIMER http://www.york.ac.uk/docs/disclaimer/email.htm

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Open Plan busyness
by Sam Johnson 04 Nov '10

04 Nov '10

Hello all, Just to let people know that between 1:15 and 3:15 this afternoon, YNiC's open plan will be very busy with the MSc course practical. This year we're pretty much at capacity so there won't be any spare machines. Those of you who are coming up for the seminar and thought about coming early to get a bit of quiet work done, I'm not sure that'll be possible I'm afraid. Apologies to those who were unable to work last week, for future reference Thursday afternoons for the next 6 weeks will be equally busy, though I'll send reminders. Thanks, Sam -- Sam Johnson Science Manager, York NeuroImaging Centre University of York http://www.ynic.york.ac.uk

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