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2770 discussions

by rem

Dear Users Today (4-5 pm in YNiC) there will be a talk by Dr. Peter van Zijl from Johns Hopkins University and the Kennedy Krieger Institute. http://www.kennedykrieger.org/kki_staff.jsp?pid=1064 The title of Dr van Zijl's talk is "Chemical Exchange Saturation Transfer (CEST) contrast agents". Please see below for the talk abstract. Everyone is welcome to attend and refreshments will be provided after the talk. Best wishes Rebecca Abstract: CEST agents1,2 exploit exchangeable protons to achieve contrast in MRI. This can be accomplished by using radiofrequency saturation at the NMR frequency of these protons and monitoring of the transfer of this saturation to the water protons imaged in MRI. When continuous saturation is applied, strong sensitivity enhancements (factors of hundred to hundreds of thousands depending on the protons) can be attained to image micromolar compounds. CEST agents have been broadly classified in terms of containing paramagnetic metals (paraCEST) or not (diaCEST). The main characteristic of diaCEST agents is that the chemical shift range of their exchangeable protons is limited to a range of approximately 6-7 ppm positive with respect to the water signal, which can be extended by another 6-7 ppm through hydrogen bonding of the exchangeable site. Currently, protons used for diaCEST include OH (hydroxyl, ~0-3ppm from water), NH2 (amine ~0-3 ppm from water), NH (amide, ~3- 4ppm from water; imino, ~5-7ppm from water). The main compounds are carbohydrates (sugars), peptides and proteins, and nucleic acids, which is important to mention because these are natural bio-organic substances. MRI is an insensitive method and, contrary to PET and optical approaches, the application of contrast agents often requires physiologically incompatible (micromolar-millimolar) concentrations. Unlike paramagnetic metallic contrast agents, diaCEST provides natural, non-metallic labels. As a consequence, this methodology has already allowed the use of many agents in vivo in animals, while endogenous markers such as cellular peptides and sugar derivatives are even been studied in humans. Recent data suggest that amide proton transfer (APT) may provide a biomarker for separating tumor recurrence from treatment necrosis in the brain. ^3 In this presentation, an overview will be given of current diaCEST agents as well as of their applications and pitfalls. Based on its non-invasive character, diaCEST is expected to revolutionize the rapid translation of contrast agents to the clinic. The field is evolving rapidly and many novel exogenous agents and endogenous markers are expected to be discovered in the near future. Reference: 1) Ward KM et al. J Magn Reson 2000;143:79–87. 2) van Zijl PC, Yadav NN. Magn Reson Med. 2011;65(4):927-48. 3) Zhou J. et al. Nat Med. 2011;17(1):130-4. -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

13 years, 8 months

YNiC seminar 24th August

by rem

Dear Users This *Wednesday* (4-5 pm in YNiC) there will be a talk by Dr. Peter van Zijl from Johns Hopkins University and the Kennedy Krieger Institute. http://www.kennedykrieger.org/kki_staff.jsp?pid=1064 The title of Dr van Zijl's talk is "Chemical Exchange Saturation Transfer (CEST) contrast agents". Please see below for the talk abstract. Everyone is welcome to attend and refreshments will be provided after the talk. Best wishes Rebecca Abstract: CEST agents^1,2 exploit exchangeable protons to achieve contrast in MRI. This can be accomplished by using radiofrequency saturation at the NMR frequency of these protons and monitoring of the transfer of this saturation to the water protons imaged in MRI. When continuous saturation is applied, strong sensitivity enhancements (factors of hundred to hundreds of thousands depending on the protons) can be attained to image micromolar compounds. CEST agents have been broadly classified in terms of containing paramagnetic metals (paraCEST) or not (diaCEST). The main characteristic of diaCEST agents is that the chemical shift range of their exchangeable protons is limited to a range of approximately 6-7 ppm positive with respect to the water signal, which can be extended by another 6-7 ppm through hydrogen bonding of the exchangeable site. Currently, protons used for diaCEST include OH (hydroxyl, ~0-3ppm from water), NH2 (amine ~0-3 ppm from water), NH (amide, ~3- 4ppm from water; imino, ~5-7ppm from water). The main compounds are carbohydrates (sugars), peptides and proteins, and nucleic acids, which is important to mention because these are natural bio-organic substances. MRI is an insensitive method and, contrary to PET and optical approaches, the application of contrast agents often requires physiologically incompatible (micromolar-millimolar) concentrations. Unlike paramagnetic metallic contrast agents, diaCEST provides natural, non-metallic labels. As a consequence, this methodology has already allowed the use of many agents in vivo in animals, while endogenous markers such as cellular peptides and sugar derivatives are even been studied in humans. Recent data suggest that amide proton transfer (APT) may provide a biomarker for separating tumor recurrence from treatment necrosis in the brain. ^3 In this presentation, an overview will be given of current diaCEST agents as well as of their applications and pitfalls. Based on its non-invasive character, diaCEST is expected to revolutionize the rapid translation of contrast agents to the clinic. The field is evolving rapidly and many novel exogenous agents and endogenous markers are expected to be discovered in the near future. Reference: 1) Ward KM et al. J Magn Reson 2000;143:79–87. 2) van Zijl PC, Yadav NN. Magn Reson Med. 2011;65(4):927-48. 3) Zhou J. et al. Nat Med. 2011;17(1):130-4. -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

13 years, 8 months

[Fwd: [megcommunity] MEG related positions at the Donders Institute/Nijmegen]

by Gary Green

FYI --------------------- Dear all, I would like to point your attention to the following MEG related positions at the Donders Institute, Nijmegen, The Netherlands. PhD position: cueing in Parkinson’s disease http://www.umcn.nl/OverUMCstRadboud/werkenbij/Pages/Vacature.aspx?VacatureN… PhD position: Bridging the Gap between Neuronal Activity and Neuroimaging http://www.ru.nl/donders/jobs/vm/vacancies/ Post doctoral fellow in sensorimotor neuroscience http://www.umcn.nl/OverUMCstRadboud/werkenbij/Pages/Vacature.aspx?VacatureN… *** <http://www.ru.nl/publish/pages/605682/phd_position_30_08_111.pdf>*** All the best, Ole -- Ole Jensen http://www.neuosc.com -- Gary Green York Neuroimaging Centre The Biocentre York Science Park Innovation Way Heslington York YO10 5DG http://www.ynic.york.ac.uk https://www.ynic.york.ac.uk/about-us/people/ggrg tel. +44 (0) 1904 435349 PA - Claire Fox : +44 (0) 1904 435329 or Claire.Fox(a)ynic.york.ac.uk fax +44 (0) 1904 435356 mobile +44 (0) 788 191 3004

13 years, 8 months

YNiC seminar today (external speaker)

by rem

Dear Users Today (4-5 pm in YNiC) there will be a talk by Dr Aneurin Kennerley from the University of Sheffield. http://www.sheffield.ac.uk/psychology/staff/research/aneurin-kennerley The title of Dr Kennerley's talk is "Concurrent 7T fMRI and 2-D Optical Imaging Spectroscopy: Towards building a forward model between neuronal activity and the BOLD signal". Please see below for the talk abstract. Everyone is welcome to attend and refreshments will be provided after the talk. Best wishes Rebecca Abstract: Functional magnetic resonance imaging (fMRI) has become the cornerstone of cognitive neuroscience in recent years. The widely used Blood Oxygenation Level Dependent (BOLD) signal is often used to interpret changes in neuronal activation. However, at present, a biophysical understanding of the neurovascular drivers of the BOLD signal is not clear and thus hinders any quantitative estimation of the underlying neuronal activity. Neuroimaging research at the University of Sheffield drives towards building a forward biophysical model of this complex relationship. As part of this multidisciplinary group my research is aimed at developing a general model of the BOLD signal which can model both intra- and extra- vascular MR signals, across a wide range of imaging parameters, from estimates of the haemodynamic changes. Validation and refinement of the haemodynamic response models underlying fMRI signals, an essential precondition for the correct interpretation of human BOLD data requires invasive multimodal animal imaging. I have developed an innovative in-vivo methodology for concurrent fMRI and 2D optical imaging spectroscopy (2D-OIS) techniques for simultaneous measurement of BOLD signal and underlying haemoglobin changes to neuronal activation in the healthy rodent model. Applications of this technology include: 1) Understanding of the negative BOLD signal (Boorman et al 2010). Most researchers assume a negative BOLD to be a result of either neuronal inhibition or vascular steal. It is only with the simultaneous, independent measurement of haemoglobin changes (with 2D-OIS) that one could disassociate any possible physiological relationships; 2) Refinement of mathematical and biophysical models of both the BOLD signal and optical imaging spectroscopy techniques (Kennerley et.al. 2009); 3) Calibration of non-BOLD fMRI techniques such as VASO and ASL; 4) Interpretation of abnormal BOLD responses; specifically in disease and trauma conditions in which either neuronal or haemodynamic breakdown could be responsible. [1] Boorman, L.W. et.al. (2010) /Journal of Neuroscience/. /30(12): 4285-94;/ [2] Kennerley, A.J. et.al (2009) /NeuroImage 47:1608-1619/; -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

13 years, 8 months

YNiC seminar 11th August (external speaker)

by rem

Dear Users This Thursday (4-5 pm in YNiC) there will be a talk by Dr Aneurin Kennerley from the University of Sheffield. http://www.sheffield.ac.uk/psychology/staff/research/aneurin-kennerley The title of Dr Kennerley's talk is "Concurrent 7T fMRI and 2-D Optical Imaging Spectroscopy: Towards building a forward model between neuronal activity and the BOLD signal". Please see below for the talk abstract. Everyone is welcome to attend and refreshments will be provided after the talk. Best wishes Rebecca Abstract: Functional magnetic resonance imaging (fMRI) has become the cornerstone of cognitive neuroscience in recent years. The widely used Blood Oxygenation Level Dependent (BOLD) signal is often used to interpret changes in neuronal activation. However, at present, a biophysical understanding of the neurovascular drivers of the BOLD signal is not clear and thus hinders any quantitative estimation of the underlying neuronal activity. Neuroimaging research at the University of Sheffield drives towards building a forward biophysical model of this complex relationship. As part of this multidisciplinary group my research is aimed at developing a general model of the BOLD signal which can model both intra- and extra- vascular MR signals, across a wide range of imaging parameters, from estimates of the haemodynamic changes. Validation and refinement of the haemodynamic response models underlying fMRI signals, an essential precondition for the correct interpretation of human BOLD data requires invasive multimodal animal imaging. I have developed an innovative in-vivo methodology for concurrent fMRI and 2D optical imaging spectroscopy (2D-OIS) techniques for simultaneous measurement of BOLD signal and underlying haemoglobin changes to neuronal activation in the healthy rodent model. Applications of this technology include: 1) Understanding of the negative BOLD signal (Boorman et al 2010). Most researchers assume a negative BOLD to be a result of either neuronal inhibition or vascular steal. It is only with the simultaneous, independent measurement of haemoglobin changes (with 2D-OIS) that one could disassociate any possible physiological relationships; 2) Refinement of mathematical and biophysical models of both the BOLD signal and optical imaging spectroscopy techniques (Kennerley et.al. 2009); 3) Calibration of non-BOLD fMRI techniques such as VASO and ASL; 4) Interpretation of abnormal BOLD responses; specifically in disease and trauma conditions in which either neuronal or haemodynamic breakdown could be responsible. [1] Boorman, L.W. et.al. (2010) /Journal of Neuroscience/. /30(12): 4285-94;/ [2] Kennerley, A.J. et.al (2009) /NeuroImage 47:1608-1619/; -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

13 years, 8 months

[Fwd: [Eeglabnews] EEGLAB multiple subject channel interpolation bug]

by Claire Fox (secretary for Gary Green)

Some users may need to be aware of this particular bug in EEG. -- Claire Fox PA to Professor Gary Green The York Neuroimaging Centre Innovation Way Science Park York YO10 5DG Tel: 01904 435329 Fax: 01904 435356 Email: Claire.fox(a)ynic.york.ac.uk

13 years, 9 months

[Fwd: [megcommunity] Invitation to contribute to a Special Issue on Brain Oscillations during Language Processing]

by Gary Green

FYI --------------------------------------- Dear colleagues, We would like to invite you to contribute your research to our special issue on the role of brain oscillations in language processing, to appear in Frontiers in Language Science. You can visit the web site at: _http://www.frontiersin.org/languagesciences/specialtopics/brain_oscillatio… See detailed description below. The call has been very successful so far and prominent figures in the field have joined us in this project. We are looking forward to receiving your research. Best wishes, Lucia Melloni & Marcela Pena *Brain Oscillations during Language Processing: from Perception to Production * /Deadline for abstract submission: 01 Sep 2011 / /Deadline for full article submission: 15 Dec 2011 / Language processing is a seemingly effortless task that requires the integration of speech units (e.g., phonemes, syllables, words, etc.) occurring at different rates. In particular, temporal binding for speech should occur within and across different temporal scales, necessitating multiple simultaneous windows of integration for prosodic, semantic, syntactic and pragmatic processing. Recent evidence suggests that neuronal oscillations may reflect both tracking linguistic units at their individual rhythms as well as integrating speech units over a large range of temporal scales. The present Research Topic would like to evaluate current theories and evidence for a mechanistic role of neuronal oscillations in measuring language processing, covering the latest advances brought about by EEG, MEG and fMRI imaging methods. Our main focus is to highlight innovative and foundational studies that go beyond methodological issues and advance our theoretical understanding of the role of brain oscillations in language processing. Contributions from the pioneers of this field are selected, illustrating how the study of brain oscillations has allowed investigating theoretically relevant questions that could not be addressed by more traditional methods. The topic thus aims at deepening our mechanistic understanding of language processing and bringing us closer to bridging the gap between brain, mind and behavior for the crucial cognitive function of speech. Hosted By: Marcela Pena <http://www.frontiersin.org/people/MarcelaPena/5634>, Catholic University of Chile, Chile Lucia Melloni <http://www.frontiersin.org/people/LuciaMelloni/32689>, Max Planck Institute for Brain Research, Germany ------------------------------ Lucia Melloni, Ph.D Max Planck Institute for Brain Research Deutschordenstr. 46 60528 Frankfurt am Main Germany lucia.melloni(a)brain.mpg.de <mailto:lucia.melloni@brain.mpg.de> T: +49 69 96769-268 <tel:%2B49%2069%2096769-268> F: +49 69 96769-327 <tel:%2B49%2069%2096769-327> -- Gary Green

13 years, 9 months

HBM Review Presentation

by michael＠ynic.york.ac.uk

Dear all, for the few of you who wanted to follow up some of the references from my talk today, I've put the presentation here: /groups/resources/hbmReview.pptx Some of the videos probably won't work, so I've added links to where they may be accessed. Michael

13 years, 9 months

[Fwd: [megcommunity] Researcher positions available at ATR, Japan]

by Gary Green

FYI -------- Original Message -------- To Whom it May Concern: ATR Neural Information Analysis Laboratories, Kyoto, Japan, have openings for researcher positions and invite applications from Ph.D. holders (or Ph.D. candidates who are very close to completion) with strong motivations and ambitions in the research project described below. Our institute ATR, located in western Japan, is one of the top research centers in computational neuroscience, biomedical signal processing, and robotics in Asia (see http://www.cns.atr.jp/en/ for more details). Our group research on brain-machine interface (BMI), which controls actuators by estimating human movement and intension from brain activities measured noninvasively by MEG, EEG, fMRI, and NIRS. In particular, we focus on developing information scientific methods, bio-measurement techniques, and neurosciences. The project for which we are recruiting aims to construct a new information-communication technology to connect people and machines through engineering applications of neuroscience. More specifically, the project's goal is to develop a BMI methodology that works well in various environments in the real world by simultaneous measurement of human behavior and brain activities and also by parallel and distributed processing of large-scale data. We look forward to your applications and recommendations. Shin Ishii ATR Neural Information Analysis Laboratories, Kyoto, Japan = Job description = (1) Ambient informatics team The researcher will join a team dedicated for establishing an environment for continuous measurement and recognition of human behavior in a daily life. Here, the "environment" includes hardware facilities, efficient network, and pattern recognition algorithms and software. The team is supported by engineers. Data measurement devices include stereo cameras, laser range finders, microphones, pyroelectric sensors, power monitors (for appliance), and bio-measurement devices (for electromyogram (EMG), heart pulse, blood pressure, perspiration, and temperature). Good proposals for additional measurement modalities will be welcomed. (2) Decoding team The researcher will join a team dedicated for developing artifact reduction and decoding algorithms for brain activities measured under real environments. Brain activity data measured in real environments would often be contaminated by non-brain signals, which must be reduced by all means for further analysis. By solving a challenging research problem of decoding of movement or intension in uncontrolled experiments, the team will develop BMI algorithms under real environments. The successful candidate should have a strong background in machine learning, information retrieval, or statistical signal processing. Excellent programming skills and experiences of large-scale data analysis will be advantageous. (3) Neurosciences team The researcher will join a team dedicated for neuroscience studies focusing on human decision making and motor control under real environments. The team's challenging goal is to elucidate the neural bases involved in decision making and motor control, which are sufficiently robust even in the uncertain real world, by fully utilizing newly developed techniques of brain machine interface. The teams include several foreign researchers and we also have collaborated closely with researchers in countries overseas. Thus, applications from abroad are particularly welcome. = Requirements = Applicants must: - have a Ph.D. (or be near completion). - have strong motivations and ambitions to take part in the research above. Also, researchers having interest in neural and human science with expertise in one or more of the following areas are welcomed: - Statistics, machine learning, parallel distributed computing, signal processing, artificial intelligence, bio-measurement and instrumentation, computer vision, statistical physics, cognitive psychology. Exceptional applicants with a master’s or equivalent degree will be considered as well. = Number of openings = Few = Employment conditions = Position : Full-time Researcher / Full-time Research Engineer Tenure : Single year based contract, renewable based on evaluation Treatment: Based on individual performance Work Location: Advanced Telecommunications Research Institute International (ATR) 2-2-2 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0288, Japan = Application materials = Please submit the following five materials to the contact address below, either in printed or electronic form: 1. CV 2. List of publications 3. Reprints of 1–3 major publications 4. Document (one or two pages in A4 or letter size) describing: - Summary of your previous research - Interests and proposal for research - Additional research skills not directly foreseeable from publications 5. Recommendation letters from two researchers * Original documents you submit will not be returned. = Judging system = After documentary examination, we ask for presentation and interview if needed = Starting date = After October 2011 (negotiable) = Deadline for application = Opens until positions are filled. = Contact = ATR Neural Information Analysis Laboratories (Application for Researcher Position) 2-2-2 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0288, Japan Email: dbi-info(a)atr.jp = Use of personal data = All personal data received will be properly managed and only be used for the purpose of recruitment. -- Gary Green

13 years, 9 months

MRI music

by Liat Levita

MRI scanner inspires a multimedia performance http://www.bbc.co.uk/news/entertainment-arts-14283203 Thought would be of interest. Liat

13 years, 9 months

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