ynic-users September 2018

ynic-users@ynic.york.ac.uk

3 participants
7 discussions

YNiC Project presentation Thursday 27th @ 4pm.

by Andre Gouws

Hi all, We will be hosting a project presentation by Bardur Joensen (Berens, Horner) at YNiC tomorrow (Thurs 27th) at 4pm: “ Tracking the retrieval of episodic events over time ”. Please join us for the presentation and discussion to be followed by light refreshments. Best wishes (and sorry for the late notice), -- André ************************************************************************ André Gouws PhD Manager of Imaging Services York Neuroimaging Centre University of York The Biocentre York Science Park Heslington YO10 5NY Tel: +44 (0) 1904 435327 Fax: +44 (0) 1904 435356

6 years, 9 months

GE scanner update

by Antony Morland

Hello All, I am happy to report that the GE scanner is now up and running. Best wishes Tony -- Antony Morland, PhD. Director, York Neuroimaging Centre Department of Psychology, University of York, York YO10 5DD, UK.

6 years, 9 months

Teaching at YNiC

by Mark Hymers

Dear all, As usual, there will be teaching in the YNiC Open plan area during the autumn and spring terms. During these times, the area will be closed to anybody not involved in the teaching. Times for the Autumn term are: Week 1: Thursday 27th September 0900-1300 Friday 28th September 0900-1300 Week 2: Tuesday 2nd October: 1200-1400 Week 4: Tuesday 16th October: 1200-1400 Week 7: Tuesday 6th November: 1200-1400 Week 9: Tuesday 20th November: 1200-1400 Times for the Spring term will be sent out during the Christmas vacation period. Thanks, Mark -- Mark Hymers, Lecturer in Neuroimaging Methods York NeuroImaging Centre and Department of Psychology University of York, UK Please note that my email address is: mark.hymers(a)ynic.york.ac.uk Responses to messages sent to other addresses may be delayed

6 years, 9 months

Upgrades and changes

by Antony Morland

Hello All, We are now open after our summer closure for upgrades and maintenance. As always, please let us know if there is anything that no longer functions as it did and we will try to rectify the situation. Here is a summary of what has been updated/upgraded during the closure: *Software*: FSLeyes upgraded to most recent version (0.26.1) Psychopy upgraded to 1.90.3 including changes to video handling (addition of moviepy and sounddevice) Matlab 9.4 added; no Matlab versions removed; 9.0 will be removed in January. Libreoffice upgraded to 6.1 Crossover Office upgraded to 17.5 Mendeley upgraded to latest release SPM 12 upgraded to latest patch (r7219) Windows is no longer supported on the Stimulus PCs *Hardware changes:*New cabling of offices Networking improvements Telephony updated New chiller installed for GE system - this should be completed by tomorrow *Estate:* The Chemistry areas have been reconfigured and rationalized Best wishes Tony -- Antony Morland, PhD. Director, York Neuroimaging Centre Department of Psychology, University of York, York YO10 5DD, UK.

6 years, 9 months

Email addresses

by Antony Morland

Hello All, We have received (indirectly) some emails asking for help. They were posted to rec-submission(a)ynic.york.ac This is the address to send ethics applications, not a email queue that we monitor for general issues. To avoid undue delays please send requests for help etc to support(a)ynic.york.ac.uk Many thanks Tony -- Antony Morland, PhD. Director, York Neuroimaging Centre Department of Psychology, University of York, York YO10 5DD, UK.

6 years, 9 months

Fwd: REMINDER - SEMINAR INFO: JEOL Postdoc Competition Winners' Seminar & refreshments, TOMORROW, 13:00, C/A/101

by Antony Morland

The second talk described below may be of interest *JEOL Postdoc Competition Winners’ Seminar * *Thursday 20th September * *13.00-15.00* *C/A101* *13.00 Dr. Aggie Lawer* *"Synthesis of functionalised peptides/macrocycles and medium-size **rings via stereoselective fluorination and SuRE/NICE chemistry"* Insertion of fluorine into organic molecules is well-known to affect the molecules’ electronic distribution and conformation in ways that can be beneficial in drug development. However, the effects of fluorination have not been widely investigated in the context of peptides, which limits the development of peptide-based drugs. In the first part of the talk, I will discuss how stereoselective fluorination was used to control the conformations of peptides and enhance the potency of a peptide-based enzyme inhibitor. While peptides/macrocycles and medium-size rings have recently gained noteworthy interest in the area of medicinal chemistry, their synthesis is mostly limited to the traditional end-to-end macrocyclisations which suffer from unfavourable thermodynamic factors, and oftentimes require the use of high dilution conditions. In the second part of my talk, I’ll describe how Successive Ring Expansion (SuRE) and N-acyl Iminium ion mediated Cyclisation/Expansion (NICE) reactions developed in Unsworth group could be employed to overcome these limitations, providing an efficient, scalable and practical route to make diverse macrocycles and medium-size rings. *13.45 Dr. Peter Rayner * *"Tunable Hyperpolarisation by Synthetic Design"* NMR and MRI are two of the most popular techniques to study molecules and materials. However, both of these approaches are insensitive and hyperpolarization methods to increase signal size are needed in order to access new applications. This talk will describe how rational synthetic design of both the contrast agents and N-heterocyclic carbene catalysts utilized in the Signal Amplification by Reversible Exchange process, have led to signals that are up to 120,000 times larger than those achieved on a typical hospital scanner and can be observed many minutes after their creation. These improvements have allowed the observation of hyperpolarized molecules by in vivo MRI techniques. *The seminar will be followed at 14.30 by refreshments* -- Antony Morland, PhD. Director, York Neuroimaging Centre Department of Psychology, University of York, York YO10 5DD, UK.

6 years, 9 months

Remote desktop

by Antony Morland

Hello All, The Remote Desktop is now up and running. We are still closed for maintenance and upgrades so while we hope the service will run uninterrupted, there may be unplanned outages. Best wishes Tony -- Antony Morland, PhD. Director, York Neuroimaging Centre Department of Psychology, University of York, York YO10 5DD, UK.

6 years, 9 months

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ynic-users September 2018