There is an additional seminar today
At 2pm
There will be a talk entitled
"NMR and MRI sensitivity enhancement by Parahydrogen Induced Polarization"
by
Kerstin Münnemann
Max Planck Institute for Polymer Research, Mainz, Germany
Despite its wide applicability in chemistry, biology and medicine,
Nuclear Magnetic Resonance (NMR) spectroscopy still suffers from its
inherently low sensitivity. Exploiting the large signal enhancements
associated with hyperpolarization techniques, such as Parahydrogen
Induced Polarization (PHIP), however, NMR or MRI qualify for monitoring
dynamic processes in real time. In this lecture, the synthesis and
hyperpolarization of several biocompatible molecules like barbiturates,
Vinylpyrrolinidon (blood plasma expander) or Dimethylcarboxylat
(precursor to fumarate) will be presented. Polarization transfer to 13C
in these molecules by using adequate pulse sequences is demonstrated.
Moreover, constant NMR signal enhancement of 1H and 13C is shown using a
continuous delivery of parahydrogen by hollow fiber membranes. This
allows the acquisition of two-dimensional NMR experiments requiring
multiple excitations with constant initial polarization. The membrane
technique can be easily extended to produce a continuous flow of a
hyperpolarized liquid as will be shown for MRI applications.
All welcome
Dear Users
Dear Users
Today (4-5 pm YNiC open plan) Matt Brookes from the University of
Nottingham will give a talk on "Brain network measurements using MEG
and ultra-high field MRI".
http://www.nottingham.ac.uk/neuroscience/contact/a-z/A-F/brookes_matt.phtml
Everyone is welcome to attend.
Best wishes
Rebecca
--
Dr. Rebecca E. Millman
York Neuroimaging Centre
The Biocentre
York Science Park
York
YO10 5DG
Email: rem(a)ynic.york.ac.uk
Tel: 01904 435 5373
FYI
-----------
*MRC Cognition and Brain Sciences Unit -- Cambridge*
*Neuroimaging Methods Post to Study Ageing*
The MRC Cognition and Brain Sciences Unit is an internationally renowned
research institute with state-of-the-art cognitive neuroscience
facilities, including Siemens 3T MRI and 306-channel Elekta-Neuromag MEG
scanners.
A 2 year post-doctoral position is available to support the
newly-established Cambridge Centre for Ageing and Neuroscience (CamCAN),
funded by the UK BBSRC in order to relate changes in the brain with
changes in cognitive function across the adult lifespan. You will be
part of a Cambridge-wide collaboration, working to develop and maintain
the storage and analysis pipelines for large quantities of MRI, fMRI and
MEG data. This post will be available from January 2011.
You will have a PhD in neuroscience, scientific computing or a related
area, plus experience of analysis of neuroimaging data, such as MRI,
fMRI and/or MEG. You should have excellent IT skills, being familiar
with Linux and Matlab, and ideally with specialised neuroimaging
analysis software. Experience of studying changes in the brain with
ageing, and of cognitive neuroscience would be an advantage. You will be
thorough, efficient, effective, a good communicator, and enjoy working
as part of a diverse and energetic team.
The starting salary will be in the range of £26,022 - £31,758 depending
upon qualifications and experience. We offer a flexible pay and reward
policy, 30 days annual leave entitlement, and an optional MRC final
salary Pension Scheme. On site car and cycle parking is available.
For informal discussion please contact Drs Rhodri Cusack or Rik Henson
by email: _rhodri.cusack(a)mrc-cbu.cam.ac.uk_
<mailto:rhodri.cusack@mrc-cbu.cam.ac.uk>/_rik.henson(a)mrc-cbu.cam.ac.uk_
<mailto:rik.henson@mrc-cbu.cam.ac.uk>.
Applications for this role must be made on line at
_http://jobs.mrc.ac.uk_ <http://jobs.mrc.ac.uk/>. If you do not have
internet access or experience technical difficulties, please contact
01793 867162, quoting reference* CBSU10/338*.
If you would like to receive this advert in large print, Braille, audio,
or electronic format/ hard copy, please contact the Recruitment team at
the MRC Shared Service Centre on the telephone number above or
_recruitment(a)ssc.mrc.ac.uk_ <mailto:recruitment@ssc.mrc.ac.uk>
*Closing Date: 20**^th ** August 2010*
The Medical Research Council is an Equal Opportunities Employer.
-------------------------------------------------------
Dr Richard Henson
Assistant Director, Neuroimaging
MRC Cognition & Brain Sciences Unit
15 Chaucer Road
Cambridge, CB2 7EF, UK
Office: +44 (0)1223 355 294 x522
Mob: +44 (0)794 1377 345
Fax: +44 (0)1223 359 062
http://www.mrc-cbu.cam.ac.uk/people/rik.henson/personal
-------------------------------------------------------
Hi,
As I mentioned a while back, just before the start of next term
(September 2010) we'll change the default Matlab version to R2010a
(7.10). This is just a reminder that it would be helpful if people
could quickly check that any extra toolboxes or scripts which they rely
on still work under 7.10 and let me know of any problems they see. If
we don't get any reports, we'll assume that it's all ok.
R2009a (7.8) will still be available until September 2011 as shown at:
https://www.ynic.york.ac.uk/doc/ITPages/FAQ/Misc/SupportedVersions#Matlab
Thank you,
Mark
--
Mark Hymers
York Neuroimaging Centre
Dear Users
This week (4-5 pm YNiC open plan) Matt Brookes from the University of
Nottingham will give a talk on "Brain network measurements using MEG and
ultra-high field MRI".
http://www.nottingham.ac.uk/neuroscience/contact/a-z/A-F/brookes_matt.phtml
Everyone is welcome to attend.
Best wishes
Rebecca
--
************************************************************************
Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre
The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904
567614 Fax: +44 (0) 1904 435356
Apologies for cross-posting this to people in several email lists
Next week we have two seminars on Thursday the 29th in the YNiC Open
Plan area.
At 2pm
There will be a talk entitled
"NMR and MRI sensitivity enhancement by Parahydrogen Induced Polarization"
by
Kerstin Münnemann
Max Planck Institute for Polymer Research, Mainz, Germany
Despite its wide applicability in chemistry, biology and medicine,
Nuclear Magnetic Resonance (NMR) spectroscopy still suffers from its
inherently low sensitivity. Exploiting the large signal enhancements
associated with hyperpolarization techniques, such as Parahydrogen
Induced Polarization (PHIP), however, NMR or MRI qualify for monitoring
dynamic processes in real time. In this lecture, the synthesis and
hyperpolarization of several biocompatible molecules like barbiturates,
Vinylpyrrolinidon (blood plasma expander) or Dimethylcarboxylat
(precursor to fumarate) will be presented. Polarization transfer to 13C
in these molecules by using adequate pulse sequences is demonstrated.
Moreover, constant NMR signal enhancement of 1H and 13C is shown using a
continuous delivery of parahydrogen by hollow fiber membranes. This
allows the acquisition of two-dimensional NMR experiments requiring
multiple excitations with constant initial polarization. The membrane
technique can be easily extended to produce a continuous flow of a
hyperpolarized liquid as will be shown for MRI applications.
All are welcome
A separate email will announce the 4pm talk
Gary
--
Gary Green
York Neuroimaging Centre
The Biocentre
York Science Park
Innovation Way
Heslington
York
YO10 5DG
http://www.ynic.york.ac.ukhttps://www.ynic.york.ac.uk/about-us/people/ggrg
tel. +44 (0) 1904 435349
PA (Richard Lee) +44 (0) 1904 435329
fax +44 (0) 1904 435356
mobile +44 (0) 788 191 3004
Hello all,
Just to let people know there there are a couple of visits to YNiC this
week that might have an impact on you. Tomorrow (Tuesday) between 1:30
and about 2:30, and Wednesday morning, between 10 and 11 there will be
groups in open plan. Both groups are pretty small and won't be using the
computers so hopefully it won't be too disruptive. There will however be
presentations, so you may rather have a late lunch tomorrow and a
prolonged coffee on Wednesday.
Thanks, and apologies for any inconvenience,
Sam
Dear Users
At this time of year it can be hard to recruit participants. It is
therefore very tempting to recruit close friends and relatives.
One of the ethical issues that arises from taking this route for
recruitment is that it might be difficult for a friend or relative to
turn down your request. Unfortunately, if they accept then it then
places you and us in a rather difficult position if an anomaly is
spotted on the scan. This is extremely difficult to deal with if the
investigator is in the control room when the anomaly is detected.
We already have a policy that prevents staff from scanning relatives. We
now will extend this to the scanning of all close relatives. I hope that
you can understand the reasons behind this decision.
The radiographers have been asked to, politely, refuse to scan relatives
of investigators.
Thanks
Gary
--
Gary Green
York Neuroimaging Centre
The Biocentre
York Science Park
Innovation Way
Heslington
York
YO10 5DG
http://www.ynic.york.ac.ukhttps://www.ynic.york.ac.uk/about-us/people/ggrg
tel. +44 (0) 1904 435349
PA (Richard Lee) +44 (0) 1904 435329
fax +44 (0) 1904 435356
mobile +44 (0) 788 191 3004
Dear All,
The booking system is now back to normal service. You will see however
that all research time is booked until the end of July. If you have an
urgent need for scan time before then, please get in touch and we will
attempt to get scans performed for you.
Best wishes
Tony
