ynic-users July 2010

ynic-users@ynic.york.ac.uk

6 participants
17 discussions

Today in YNiC
by Gary Green 29 Jul '10

29 Jul '10

There is an additional seminar today At 2pm There will be a talk entitled "NMR and MRI sensitivity enhancement by Parahydrogen Induced Polarization" by Kerstin Münnemann Max Planck Institute for Polymer Research, Mainz, Germany Despite its wide applicability in chemistry, biology and medicine, Nuclear Magnetic Resonance (NMR) spectroscopy still suffers from its inherently low sensitivity. Exploiting the large signal enhancements associated with hyperpolarization techniques, such as Parahydrogen Induced Polarization (PHIP), however, NMR or MRI qualify for monitoring dynamic processes in real time. In this lecture, the synthesis and hyperpolarization of several biocompatible molecules like barbiturates, Vinylpyrrolinidon (blood plasma expander) or Dimethylcarboxylat (precursor to fumarate) will be presented. Polarization transfer to 13C in these molecules by using adequate pulse sequences is demonstrated. Moreover, constant NMR signal enhancement of 1H and 13C is shown using a continuous delivery of parahydrogen by hollow fiber membranes. This allows the acquisition of two-dimensional NMR experiments requiring multiple excitations with constant initial polarization. The membrane technique can be easily extended to produce a continuous flow of a hyperpolarized liquid as will be shown for MRI applications. All welcome

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(no subject)
by Rebecca E Millman 29 Jul '10

29 Jul '10

Dear Users Dear Users Today (4-5 pm YNiC open plan) Matt Brookes from the University of Nottingham will give a talk on "Brain network measurements using MEG and ultra-high field MRI". http://www.nottingham.ac.uk/neuroscience/contact/a-z/A-F/brookes_matt.phtml Everyone is welcome to attend. Best wishes Rebecca -- Dr. Rebecca E. Millman York Neuroimaging Centre The Biocentre York Science Park York YO10 5DG Email: rem(a)ynic.york.ac.uk Tel: 01904 435 5373

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[Fwd: [SPM] Postdoc Position at CBU, Cambridge, UK]
by Gary Green 27 Jul '10

27 Jul '10

FYI ----------- *MRC Cognition and Brain Sciences Unit -- Cambridge* *Neuroimaging Methods Post to Study Ageing* The MRC Cognition and Brain Sciences Unit is an internationally renowned research institute with state-of-the-art cognitive neuroscience facilities, including Siemens 3T MRI and 306-channel Elekta-Neuromag MEG scanners. A 2 year post-doctoral position is available to support the newly-established Cambridge Centre for Ageing and Neuroscience (CamCAN), funded by the UK BBSRC in order to relate changes in the brain with changes in cognitive function across the adult lifespan. You will be part of a Cambridge-wide collaboration, working to develop and maintain the storage and analysis pipelines for large quantities of MRI, fMRI and MEG data. This post will be available from January 2011. You will have a PhD in neuroscience, scientific computing or a related area, plus experience of analysis of neuroimaging data, such as MRI, fMRI and/or MEG. You should have excellent IT skills, being familiar with Linux and Matlab, and ideally with specialised neuroimaging analysis software. Experience of studying changes in the brain with ageing, and of cognitive neuroscience would be an advantage. You will be thorough, efficient, effective, a good communicator, and enjoy working as part of a diverse and energetic team. The starting salary will be in the range of £26,022 - £31,758 depending upon qualifications and experience. We offer a flexible pay and reward policy, 30 days annual leave entitlement, and an optional MRC final salary Pension Scheme. On site car and cycle parking is available. For informal discussion please contact Drs Rhodri Cusack or Rik Henson by email: _rhodri.cusack(a)mrc-cbu.cam.ac.uk_ <mailto:rhodri.cusack@mrc-cbu.cam.ac.uk>/_rik.henson(a)mrc-cbu.cam.ac.uk_ <mailto:rik.henson@mrc-cbu.cam.ac.uk>. Applications for this role must be made on line at _http://jobs.mrc.ac.uk_ <http://jobs.mrc.ac.uk/>. If you do not have internet access or experience technical difficulties, please contact 01793 867162, quoting reference* CBSU10/338*. If you would like to receive this advert in large print, Braille, audio, or electronic format/ hard copy, please contact the Recruitment team at the MRC Shared Service Centre on the telephone number above or _recruitment(a)ssc.mrc.ac.uk_ <mailto:recruitment@ssc.mrc.ac.uk> *Closing Date: 20**^th ** August 2010* The Medical Research Council is an Equal Opportunities Employer. ------------------------------------------------------- Dr Richard Henson Assistant Director, Neuroimaging MRC Cognition & Brain Sciences Unit 15 Chaucer Road Cambridge, CB2 7EF, UK Office: +44 (0)1223 355 294 x522 Mob: +44 (0)794 1377 345 Fax: +44 (0)1223 359 062 http://www.mrc-cbu.cam.ac.uk/people/rik.henson/personal -------------------------------------------------------

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Matlab versions
by Mark Hymers 27 Jul '10

27 Jul '10

Hi, As I mentioned a while back, just before the start of next term (September 2010) we'll change the default Matlab version to R2010a (7.10). This is just a reminder that it would be helpful if people could quickly check that any extra toolboxes or scripts which they rely on still work under 7.10 and let me know of any problems they see. If we don't get any reports, we'll assume that it's all ok. R2009a (7.8) will still be available until September 2011 as shown at: https://www.ynic.york.ac.uk/doc/ITPages/FAQ/Misc/SupportedVersions#Matlab Thank you, Mark -- Mark Hymers York Neuroimaging Centre

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YNiC seminar 29th July
by Rebecca E Millman 26 Jul '10

26 Jul '10

Dear Users This week (4-5 pm YNiC open plan) Matt Brookes from the University of Nottingham will give a talk on "Brain network measurements using MEG and ultra-high field MRI". http://www.nottingham.ac.uk/neuroscience/contact/a-z/A-F/brookes_matt.phtml Everyone is welcome to attend. Best wishes Rebecca -- ************************************************************************ Dr. Rebecca E. Millman Science Liaison Officer York Neuroimaging Centre The Biocentre York Science Park Heslington YO10 5DG Tel: +44 (0) 1904 567614 Fax: +44 (0) 1904 435356

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Seminar next week
by Gary Green 23 Jul '10

23 Jul '10

Apologies for cross-posting this to people in several email lists Next week we have two seminars on Thursday the 29th in the YNiC Open Plan area. At 2pm There will be a talk entitled "NMR and MRI sensitivity enhancement by Parahydrogen Induced Polarization" by Kerstin Münnemann Max Planck Institute for Polymer Research, Mainz, Germany Despite its wide applicability in chemistry, biology and medicine, Nuclear Magnetic Resonance (NMR) spectroscopy still suffers from its inherently low sensitivity. Exploiting the large signal enhancements associated with hyperpolarization techniques, such as Parahydrogen Induced Polarization (PHIP), however, NMR or MRI qualify for monitoring dynamic processes in real time. In this lecture, the synthesis and hyperpolarization of several biocompatible molecules like barbiturates, Vinylpyrrolinidon (blood plasma expander) or Dimethylcarboxylat (precursor to fumarate) will be presented. Polarization transfer to 13C in these molecules by using adequate pulse sequences is demonstrated. Moreover, constant NMR signal enhancement of 1H and 13C is shown using a continuous delivery of parahydrogen by hollow fiber membranes. This allows the acquisition of two-dimensional NMR experiments requiring multiple excitations with constant initial polarization. The membrane technique can be easily extended to produce a continuous flow of a hyperpolarized liquid as will be shown for MRI applications. All are welcome A separate email will announce the 4pm talk Gary -- Gary Green York Neuroimaging Centre The Biocentre York Science Park Innovation Way Heslington York YO10 5DG http://www.ynic.york.ac.uk https://www.ynic.york.ac.uk/about-us/people/ggrg tel. +44 (0) 1904 435349 PA (Richard Lee) +44 (0) 1904 435329 fax +44 (0) 1904 435356 mobile +44 (0) 788 191 3004

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Re: Job offer
by Gary Green 21 Jul '10

21 Jul '10

Wolfgang.Kilian(a)ptb.de wrote: > More information may be found on the web > > http://www.ptb.de/de/jobsausbildung/stellen/index.php?id=1163&no_cache=1&L=… > [tt_news]=2604&tx_ttnews[backPid]=96&cHash=d8268827b6 > http://ib.ptb.de/en/org/8/81/811/ResearchTopics/Hyperpolarization.html > > > > > Best regards > > Dr. Wolfgang Kilian > Physikalisch-Technische Bundesanstalt > Abbestr. 2-12 > 10587 Berlin > > Tel.: ++49-30-3481-7952 > Fax.: ++49-30-3481-7507 > E-Mail: wolfgang.kilian(a)ptb.de

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Visitors to YNiC
by Sam Johnson 19 Jul '10

19 Jul '10

Hello all, Just to let people know there there are a couple of visits to YNiC this week that might have an impact on you. Tomorrow (Tuesday) between 1:30 and about 2:30, and Wednesday morning, between 10 and 11 there will be groups in open plan. Both groups are pretty small and won't be using the computers so hopefully it won't be too disruptive. There will however be presentations, so you may rather have a late lunch tomorrow and a prolonged coffee on Wednesday. Thanks, and apologies for any inconvenience, Sam

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Important issue about scanning
by Gary Green 14 Jul '10

14 Jul '10

Dear Users At this time of year it can be hard to recruit participants. It is therefore very tempting to recruit close friends and relatives. One of the ethical issues that arises from taking this route for recruitment is that it might be difficult for a friend or relative to turn down your request. Unfortunately, if they accept then it then places you and us in a rather difficult position if an anomaly is spotted on the scan. This is extremely difficult to deal with if the investigator is in the control room when the anomaly is detected. We already have a policy that prevents staff from scanning relatives. We now will extend this to the scanning of all close relatives. I hope that you can understand the reasons behind this decision. The radiographers have been asked to, politely, refuse to scan relatives of investigators. Thanks Gary -- Gary Green York Neuroimaging Centre The Biocentre York Science Park Innovation Way Heslington York YO10 5DG http://www.ynic.york.ac.uk https://www.ynic.york.ac.uk/about-us/people/ggrg tel. +44 (0) 1904 435349 PA (Richard Lee) +44 (0) 1904 435329 fax +44 (0) 1904 435356 mobile +44 (0) 788 191 3004

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Busy times
by Antony Morland 09 Jul '10

09 Jul '10

Dear All, The booking system is now back to normal service. You will see however that all research time is booked until the end of July. If you have an urgent need for scan time before then, please get in touch and we will attempt to get scans performed for you. Best wishes Tony

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ynic-users July 2010