The notice about this afternoon's seminars said that the talks are
project presentations. In fact they are presentations about current
research in Aberdeen and are part of on-going discussions about
potential collaboration between York and Aberdeen.
Gary
--
Gary Green
York Neuroimaging Centre
The Biocentre
York Science Park
Innovation Way
Heslington
York
YO10 5DG
http://www.ynic.york.ac.ukhttps://www.ynic.york.ac.uk/about-us/people/ggrg
tel. +44 (0) 1904 435349
PA (Claire Fox) +44 (0) 1904 435329
fax +44 (0) 1904 435356
mobile +44 (0) 788 191 3004
Dear Users
Today from 4-5 pm in YNiC open plan there will be 3 project proposal
presentations:
i) Prof. David Lurie
"Field-Cycling Magnetic Resonance Imaging"
Contrast between normal and diseased tissue in MRI arises mainly from
differences in relaxation times. It is also well known from in vitro
studies that the variation of T1 with field strength (T1 dispersion)
changes from tissue to tissue, and may also be altered in disease. Thus,
it is potentially useful to be able to measure T1 dispersion in vivo;
however, this information cannot be obtained by conventional MRI
scanners, which operate at fixed magnetic field. We are developing
field-cycling MRI systems, in which the magnetic field is switched
rapidly between levels during the pulse sequence, always returning to
the same field for signal measurement. FC-MRI offers the possibility of
new image contrast mechanisms based on T1 dispersion. In particular,
immobilised proteins give rise to "quadrupole dips" in the dispersion
curve, and this mechanism may give insight into the behaviour (and
misbehaviour) of proteins in disease. This talk will discuss the
methodology, technology and applications of FC-MRI.
ii) Prof. Thomas Redpath
"Dynamic contrast-enhanced MRI in breast cancer".
My talk will cover the basic physiology underlying dynamic
contrast-enhanced MRI, the scanning methods used, and will describe the
pharmaco-kinetic models used in analysing the signal versus time curves
which are seen in breast cancers. The need for arterial input functions
in the newer models will be discussed and a novel approach which we have
proposed will be outlined. The particular problem of scanning at 3
tesla, namely RF pulse angle variation across the body, and methods of
overcoming it will also be covered.
iii) Dr. Hugh Seton
"Ultra-low field MRI with cooled receiver coils and SQUID preamplifiers"
"The presentation will describe MRI developments at 10-20mT. Imaging at
such low fields has the potential to deliver improved contrast compared
to high field, partly because T1 differences between tissues can
increase at low field but also because there is greater flexibility to
employ contrast-enhancing pulse sequences which would exceed RF power
deposition limits at high field. Normally the SNR is poor at low field,
but we have developed cooled receiver coils and ultra-low noise SQUID
preamplifiers that yield 3-6 fold SNR gains compared to conventional
room temperature coils."
Everyone is welcome to attend and refreshments will be available afterwards.
Best wishes
Rebecca
--
************************************************************************
Dr. Rebecca E. Millman
Science Liaison Officer
York Neuroimaging Centre
The Biocentre
York Science Park
Heslington
YO10 5DG
Tel: +44 (0) 1904 567614
Fax: +44 (0) 1904 435356
Dear Users
Today from 4-5 pm in YNiC open plan, Susanne Weis and Markus Hausmann
will be giving YNiC project proposal presentations.
i) Susanne Weis: "Object location memory: Differences between verbal and
non-verbal strategies during memory encoding and retrieval"
It has repeatedly been shown that the medial temporal lobe (MTL), and
especially the hippocampus, play an important role during memory
encoding and retrieval. Specifically,activation of the hippocampus has
been related to associative and contextual memory and binding of an item
with its context. It is therefore assumed, that the hippocampus
interacts with cortical regions during object location memory (OLM)
tasks, where an object has to be bound to its spatial location. A
variety of studies have shown that men on average perform better than
women in specific aspects of spatial cognition. On the other hand, women
have been shown to be superior in OLM tasks. One explanation which has
been proposed for this findings suggests that women use verbal
strategies during OLM encoding and retrieval, while man rely more on
spatial strategies. It can be assumed that different strategies during
OLM task are linked to different patterns of brain activation. It is the
aim of our study to examine functional connectivity between the
hippocampus and cortical areas during encoding and retrieval of an OLM
task. Further, we intend to find out if inter-individual differences in
strategies result in changes of patterns of brain activation and the
functional connectivity within these networks.
ii) Markus Hausmann: "Sex hormonal effects on the functional
connectivity within and across hemispheres in postmenopausal women"
Previous research in postmenopausal women has shown that hormone therapy
(HT), and estrogen therapy (ET) in particular, affects the functional
brain organization such as interhemispheric integration and functional
cerebral asymmetries (FCAs) (Bayer & Erdmann, 2008; Bayer & Hausmann,
2009a,b; Bayer & Hausmann, 2010). The results suggest that these effects
are mediated by the neuromodulatory properties of estradiol on
intrahemispheric functional networks. Specifically, it seems that
estradiol enhances verbal processing at the expense of visuo-spatial
processing within the right hemisphere. This idea might explain why
several studies found divergent effects of HT on verbal and
visuo-spatial cognition (including verbal and non-verbal memory).
Moreover, estradiol-related effects on FCAs have also been demonstrated
in normally cycling women during hormonal distinct cycle-phases (Weis et
al., 2008). Specifically, this fMRI study found estradiol-related
changes in the interhemispheric inhibition between homotopic areas in
the inferior frontal gyrus of the left and right hemispheres. The
present study is set out to elucidate whether HT-related changes in FCAs
as measured by a verbal and visuo-spatial visual half-field tasks in
postmenopausal women might be subserved by changes in the functional
connectivity between cortical networks within and across hemispheres.
Everyone is welcome to attend.
Best wishes
Rebecca
--
************************************************************************
Dr. Rebecca E. Millman
Science Liaison Officer
York Neuroimaging Centre
The Biocentre
York Science Park
Heslington
YO10 5DG
Tel: +44 (0) 1904 567614
Fax: +44 (0) 1904 435356
Dear Users
Please note that there will be two YNiC seminars this week; one at the
usual time on Thursday and an additional seminar on Wednesday afternoon.
On Wednesday Dr. Susanne Weis and Dr. Markus Hausmann, from the
University of Durham, will give project proposal presentations from 4-5 pm:
Dr. Susanne Weis: "Object location memory: Differences between verbal
and non-verbal strategies during memory encoding and retrieval"
Dr. Markus Hausmann: ""Sex hormonal effects on the functional
connectivity within and across hemispheres in postmenopausal women"
On Thursday there will be 3 project proposal presentations by Prof.
David Lurie, Prof. Thomas Redpath and Dr. Hugh Seton from the University
of Aberdeen:
Prof. David Lurie: ""Field-Cycling Magnetic Resonance Imaging"
Prof. Thomas Redpath: "Dynamic contrast-enhanced MRI in breast cancer"
Dr. Hugh Seton: "Ultra-low field MRI with cooled receiver coils and
SQUID preamplifiers"
Please see below for further information about each talk.
Everyone is welcome to attend and refreshments will be available afterwards.
Best wishes
Rebecca
*1) Wednesday 10th November *
i) Susanne Weis
"Object location memory: Differences between verbal and non-verbal
strategies during memory encoding and retrieval"
It has repeatedly been shown that the medial temporal lobe (MTL), and
especially the hippocampus, play an important role during memory
encoding and retrieval. Specifically,activation of the hippocampus has
been related to associative and contextual memory and binding of an item
with its context. It is therefore assumed, that the hippocampus
interacts with cortical regions during object location memory (OLM)
tasks, where an object has to be bound to its spatial location. A
variety of studies have shown that men on average perform better than
women in specific aspects of spatial cognition. On the other hand, women
have been shown to be superior in OLM tasks. One explanation which has
been proposed for this findings suggests that women use verbal
strategies during OLM encoding and retrieval, while man rely more on
spatial strategies. It can be assumed that different strategies during
OLM task are linked to different patterns of brain activation. It is the
aim of our study to examine functional connectivity between the
hippocampus and cortical areas during encoding and retrieval of an OLM
task. Further, we intend to find out if inter-individual differences in
strategies result in changes of patterns of brain activation and the
functional connectivity within these networks.
ii) Markus Hausmann
"Sex hormonal effects on the functional connectivity within and across
hemispheres in postmenopausal women"
Previous research in postmenopausal women has shown that hormone therapy
(HT), and estrogen therapy (ET) in particular, affects the functional
brain organization such as interhemispheric integration and functional
cerebral asymmetries (FCAs) (Bayer & Erdmann, 2008; Bayer & Hausmann,
2009a,b; Bayer & Hausmann, 2010). The results suggest that these effects
are mediated by the neuromodulatory properties of estradiol on
intrahemispheric functional networks. Specifically, it seems that
estradiol enhances verbal processing at the expense of visuo-spatial
processing within the right hemisphere. This idea might explain why
several studies found divergent effects of HT on verbal and
visuo-spatial cognition (including verbal and non-verbal memory).
Moreover, estradiol-related effects on FCAs have also been demonstrated
in normally cycling women during hormonal distinct cycle-phases (Weis et
al., 2008). Specifically, this fMRI study found estradiol-related
changes in the interhemispheric inhibition between homotopic areas in
the inferior frontal gyrus of the left and right hemispheres. The
present study is set out to elucidate whether HT-related changes in FCAs
as measured by a verbal and visuo-spatial visual half-field tasks in
postmenopausal women might be subserved by changes in the functional
connectivity between cortical networks within and across hemispheres.
*2) Thursday 11th November *
i) Prof. David Lurie
"Field-Cycling Magnetic Resonance Imaging"
Contrast between normal and diseased tissue in MRI arises mainly from
differences in relaxation times. It is also well known from in vitro
studies that the variation of T1 with field strength (T1 dispersion)
changes from tissue to tissue, and may also be altered in disease. Thus,
it is potentially useful to be able to measure T1 dispersion in vivo;
however, this information cannot be obtained by conventional MRI
scanners, which operate at fixed magnetic field. We are developing
field-cycling MRI systems, in which the magnetic field is switched
rapidly between levels during the pulse sequence, always returning to
the same field for signal measurement. FC-MRI offers the possibility of
new image contrast mechanisms based on T1 dispersion. In particular,
immobilised proteins give rise to "quadrupole dips" in the dispersion
curve, and this mechanism may give insight into the behaviour (and
misbehaviour) of proteins in disease. This talk will discuss the
methodology, technology and applications of FC-MRI.
ii) Prof. Thomas Redpath
"Dynamic contrast-enhanced MRI in breast cancer".
My talk will cover the basic physiology underlying dynamic
contrast-enhanced MRI, the scanning methods used, and will describe the
pharmaco-kinetic models used in analysing the signal versus time curves
which are seen in breast cancers. The need for arterial input functions
in the newer models will be discussed and a novel approach which we have
proposed will be outlined. The particular problem of scanning at 3
tesla, namely RF pulse angle variation across the body, and methods of
overcoming it will also be covered.
iii) Dr. Hugh Seton
"Ultra-low field MRI with cooled receiver coils and SQUID preamplifiers"
"The presentation will describe MRI developments at 10-20mT. Imaging at
such low fields has the potential to deliver improved contrast compared
to high field, partly because T1 differences between tissues can
increase at low field but also because there is greater flexibility to
employ contrast-enhancing pulse sequences which would exceed RF power
deposition limits at high field. Normally the SNR is poor at low field,
but we have developed cooled receiver coils and ultra-low noise SQUID
preamplifiers that yield 3-6 fold SNR gains compared to conventional
room temperature coils."
--
************************************************************************
Dr. Rebecca E. Millman
Science Liaison Officer
York Neuroimaging Centre
The Biocentre
York Science Park
Heslington
YO10 5DG
Tel: +44 (0) 1904 567614
Fax: +44 (0) 1904 435356
*Assistant or Associate Research Professors, Center for Mind/Brain
Sciences, Trento *
The Center for Mind/Brain Sciences (CIMeC) at the University of Trento
is seeking to fill a number of research positions in cognitive
neuroscience at the Assistant or Associate Research Professor level. The
Center offers an international and vibrant research setting in which to
investigate the functioning of the brain through the analysis of its
functional, structural and physiological characteristics, in both normal
and pathological states. Researchers at the Center make use of
state-of-the-art neuroimaging methodologies, including a research-only
MRI scanner, MEG, EEG and TMS, as well as behavioral, eye tracking and
motion tracking laboratories. The Center also includes a neuropsychology
and neuro-rehabilitation clinic (CERiN). The Center strongly encourages
collaborative and innovative research, and provides the opportunity for
all researchers to access laboratory resources and to be part of the
Doctoral School in Cognitive and Brain Sciences. CIMeC also has close
collaborations with local research centers, including FBK (Fondazione
Bruno Kessler) and IIT (Italian Institute of Technology), through joint
projects and through the doctoral school. Further information about the
Center can be found at: http://www.cimec.unitn.it
<http://www.cimec.unitn.it/>.
The ideal researchers (from all areas of cognitive neuroscience,
including computational neuroscience and neuroimaging methods) must hold
the Ph.D. or M.D. degree, and should have a record documenting research
creativity, independence, and productivity. We are looking for
researchers able to build and maintain a high quality research program
and to contribute to the maintenance of a collegial and collaborative
academic environment.
For more information see attachment.
--
Dr Silke Goebel
Department of Psychology
University of York
Heslington
York YO10 5DD
UK
Tel: +44 (0) 1904 32 2872
Email: s.goebel(a)psych.york.ac.uk
Web: http://www.york.ac.uk/res/crl/sgoebel.html
TMS Lab: http://www.york.ac.uk/res/tms
EMAIL DISCLAIMER http://www.york.ac.uk/docs/disclaimer/email.htm
Hello all,
Just to let people know that between 1:15 and 3:15 this afternoon,
YNiC's open plan will be very busy with the MSc course practical. This
year we're pretty much at capacity so there won't be any spare machines.
Those of you who are coming up for the seminar and thought about coming
early to get a bit of quiet work done, I'm not sure that'll be possible
I'm afraid. Apologies to those who were unable to work last week, for
future reference Thursday afternoons for the next 6 weeks will be
equally busy, though I'll send reminders.
Thanks,
Sam
--
Sam Johnson
Science Manager, York NeuroImaging Centre
University of York
http://www.ynic.york.ac.uk
Dear Users
Mark Hymers will be giving a presentation from 4-5 pm in YNiC open plan
today.
The title of Mark's talk is "YNiC MEG Analysis Software Update".
Everyone is welcome to attend and refreshments will be available
afterwards.
Best wishes
Rebecca
--
************************************************************************
Dr. Rebecca E. Millman
Science Liaison Officer
York Neuroimaging Centre
The Biocentre
York Science Park
Heslington
YO10 5DG
Tel: +44 (0) 1904 567614
Fax: +44 (0) 1904 435356
Dear Users
This week Mark Hymers will be giving a presentation on Thursday
afternoon (4-5 pm) in YNiC open plan.
The title of Mark's talk is "YNiC MEG Analysis Software Update".
Everyone is welcome to attend and refreshments will be available afterwards.
Best wishes
Rebecca
--
************************************************************************
Dr. Rebecca E. Millman
Science Liaison Officer
York Neuroimaging Centre
The Biocentre
York Science Park
Heslington
YO10 5DG
Tel: +44 (0) 1904 567614
Fax: +44 (0) 1904 435356
